174599-87-2

Upstream product

• 123565-82-2 ethyl 5-cyano-1-(4-methoxyphenyl)-4-methyl-6-oxo-1,6-dihydropyridazine-3-carboxylate 

Downstream Products

• 201280-40-2 5-Cyano-1-(4-methoxy-phenyl)-4-methyl-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid [1-furan-2-yl-meth-(E)-ylidene]-hydrazide 
• 128639-57-6 5-cyano-1-(4-methoxy-phenyl)-4-methyl-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid 
• 201280-41-3 5-Cyano-1-(4-methoxy-phenyl)-4-methyl-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid [1-(4-hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide 
• 201280-39-9 5-Cyano-1-(4-methoxy-phenyl)-4-methyl-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid [1-phenyl-meth-(E)-ylidene]-hydrazide 
• 174599-91-8 5-Cyano-1-(4-methoxy-phenyl)-4-methyl-6-oxo-1,6-dihydro-pyridazine-3-carbonyl azide 

Relevant academic research and scientific papers

Polyfunctionally substituted heterocycles: Synthesis of new polyfunctionally substituted phthalazines, pyrido[3,4-C]pyridazines and pyrazolo[3,4-C]pyridazines

Several new alkylpyridine and pyridazine derivatives have been synthesized. The reactivity of these alkylazines towards aromatic aldehydes and sulphur are reported. New syntheses of pyrido[3,4-C]pyridines and phthalazines were achieved.

Novel Synthesis of Pyridopyridazine, Pyrrolopyridazine and some Pyridazine Derivatives

Ethyl-1-aryl-5-cyano-1,6-dihydro-4-methyl-6-oxopyridazin-3-carboxylates (1) react with hydrazine hydrate in ethanol to give the corresponding hydrazide (2).Compounds 2 gave the carboazides 3 upon treatment with nitrous acid.The carboazides (3) react with different alcohols, different amines and hydrazine hydrate to give the corresponding carbamate, substituted urea, and semicarbazide derivatives 5-7, respectively.Also compound 3 when refluxed in xylene gave pyrrolopyridazine (4).Compound 1 reacts with aromatic aldehydes to give styryl derivative 8 which upon refluxing with hydrazine hydrate gave the corresponding hydrazide (9) which undergoes cyclization to pyrido-pyridazine (10) upon treatment with Cu2Cl2.Key words: pyridazine, pyrrolopyridazine, pyridopyridazine

Novel synthesis of pyridopyridazine, pyrrolopyridazine and some pyridazine derivatives

Ethyl-1-aryl-5-cyano-1,6-dihydro-4-methyl-6-oxopyridazine-3-carboxylat e (1) reacts with hydrazine hydrate in ethanol to give the corresponding hydrazide 2. Compound 2 gave the carboazide 3 upon treatment with nitrous acid. The carboazide 3 reacts with different alcohols, hydrazine hydrate, and different amines to give the corresponding carbamate, semicarbazide and urea derivatives 4-6, respectively, also compound 3 when refluxed in xylene gave pyrrolopyridazine 7. Compound 1 reacts with aromatic aldehydes to give styryl derivative 8 which upon refluxing with hydrazine hydrate gave the corresponding hydrazide 9 which undergoes cyclization to pyridopyridazine 10 upon treatment with Cu2Cl2.