174681-05-1Relevant articles and documents
Gold-catalyzed asymmetric allylic substitution of free alcohols: An enantioselective approach to chiral chromans with quaternary stereocenters for the synthesis of Vitamin E and analogues
Uria, Uxue,Vila, Carlos,Lin, Ming-Yuan,Rueping, Magnus
, p. 13913 - 13917 (2014)
The enantioselective synthesis of α- and γ-tocopherol (the most biologically active members of vitamin E family) and analogues has been accomplished employing a new enantioselective gold catalyzed intramolecular allylic alkylation reaction followed by an olefin cross-metathesis as key steps. The methodology proved to be applicable to different olefins highlighting its potential for the synthesis of diverse libraries. The enantioselective synthesis of α- and γ-tocopherol (the most biologically active members of vitamin E family) and analogues has been accomplished employing an enantioselective gold-catalyzed intramolecular allylic alkylation reaction followed by an olefin cross-metathesis as key steps (see scheme).
Chiral palladium complex-catalyzed synthesis of optically active vinylchroman
Mizuguchi,Achiwa
, p. 1209 - 1211 (2007/10/03)
Optically active vinylchroman (1) was synthesized from a corresponding allyl carbonate (2) by catalytic and asymmetric allylic substitution with palladium complexes of chiral bisphosphine ligands. The reactivity and selectivity of the various chiral bisph
