174690-76-7

Upstream product

• 7766-51-0 4-iodobut-1-ene 
• 112741-50-1 (2S,3R)-tert-butyl 6-oxo-2,3-diphenylmorpholine-4-carboxylate 

Downstream Products

• 174690-79-0 C₄₅H₄₈N₂O₈ 
• 174690-77-8 (3R,5R,6S)-2-Oxo-3-(3-oxo-propyl)-5,6-diphenyl-morpholine-4-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Asymmetric syntheses of (2S,3S,6S)-, (2S,3S,6R)-, and (2R,3R,6S)-2,3-methano-2,6-diaminopimelic acids. Studies directed to the design of novel substrate-based inhibitors of L,L-diaminopimelate epimerase

The asymmetric syntheses of (2S,3S,6S)-, (2S,3S,6R)-, and (2R,3R,6S)-2,3-methano-2,6-diaminopimelic acids (7a-c) is described. The synthesis features phosphonate coupling of 13 and 14 to form the corresponding E-olefins which are subsequently cyclopropanated and deprotected under dissolving metal conditions.

TOLL LIKE RECEPTOR MODULATOR COMPOUNDS

The present disclosure relates generally to toll like receptor modulator compounds, such as diamino pyrido[3,2 D]pyrimidine compounds and pharmaceutical compositions which, among other things, modulate toll-like receptors (e.g. TLR-8), and methods of making and using them.

Asymmetric Synthesis of 2,6-Diaminopimelic Acids

The preparations of (R,R)-2,6-diaminopimelic acid, (S,S)-2,6-diaminopimelic acid, (S,R)-2,6-diaminopimelic acid, and (S,S)-2,7-diaminosuberic acid are described.The synthesis of mono-N-protected (S,R)-2,6-diaminopimelic acid is also described.