174690-77-8

Upstream product

• 112741-50-1 (2S,3R)-tert-butyl 6-oxo-2,3-diphenylmorpholine-4-carboxylate 
• 174690-76-7 (3R,5R,6S)-tert-butyl 3-(but-3-en-1-yl)-2-oxo-5,6-diphenylmorpholine-4-carboxylate 

Downstream Products

• 174690-79-0 C₄₅H₄₈N₂O₈ 

Relevant academic research and scientific papers

Asymmetric syntheses of (2S,3S,6S)-, (2S,3S,6R)-, and (2R,3R,6S)-2,3-methano-2,6-diaminopimelic acids. Studies directed to the design of novel substrate-based inhibitors of L,L-diaminopimelate epimerase

The asymmetric syntheses of (2S,3S,6S)-, (2S,3S,6R)-, and (2R,3R,6S)-2,3-methano-2,6-diaminopimelic acids (7a-c) is described. The synthesis features phosphonate coupling of 13 and 14 to form the corresponding E-olefins which are subsequently cyclopropanated and deprotected under dissolving metal conditions.

Asymmetric Synthesis of 2,6-Diaminopimelic Acids

The preparations of (R,R)-2,6-diaminopimelic acid, (S,S)-2,6-diaminopimelic acid, (S,R)-2,6-diaminopimelic acid, and (S,S)-2,7-diaminosuberic acid are described.The synthesis of mono-N-protected (S,R)-2,6-diaminopimelic acid is also described.