174709-60-5

Upstream product

• 4403-78-5 ditosylethylenediamine 
• 627-18-9 1-bromo-3-propanol 
• 98-59-9 p-toluenesulfonyl chloride 
• 32705-91-2 ethylenediamine-N,N'-di-3-propionic acid dihydrochloride salt 
• 627-30-5 1-chloro-3-hydroxypropane 
• 55910-15-1 3-[{2-[(2-Carboxy-ethyl)-(toluene-4-sulfonyl)-amino]-ethyl}-(toluene-4-sulfonyl)-amino]-propionic acid 

Downstream Products

• 174709-61-6 N,N'-ethylenebis-<3-(p-toluenesulphonylamino)propyl methanesulphonate> 
• 174709-65-0 3-[1,4,8,11-Tetrakis-(toluene-4-sulfonyl)-1,4,8,11-tetraaza-cyclotetradec-2-yl]-propionic acid ethyl ester 
• 174709-62-7 1,4,8,11-Tetrakis-(toluene-4-sulfonyl)-1,4,8,11-tetraaza-cyclotetradecane-2-carboxylic acid methoxy-methyl-amide 
• 174709-63-8 1,4,8,11-Tetrakis-(toluene-4-sulfonyl)-1,4,8,11-tetraaza-cyclotetradecane-2-carbaldehyde 
• 174709-66-1 3-[1,4,8,11-Tetrakis-(toluene-4-sulfonyl)-1,4,8,11-tetraaza-cyclotetradec-2-yl]-propan-1-ol 
• 174709-67-2 2-(3-Bromo-propyl)-1,4,8,11-tetrakis-(toluene-4-sulfonyl)-1,4,8,11-tetraaza-cyclotetradecane 
• 271253-09-9 C₄₅H₅₈N₄O₉S₄ 
• 261900-37-2 C₂₉H₃₈N₂O₆S₂ 
• 223704-08-3 (R,R)-2,6,10,13,17,21-hexakis(p-toluenesulphonyl)-2,6,10,13,17,21-hexaazabicyclo<20.4.0>hexaicosane 

Relevant academic research and scientific papers

Design and synthesis of pyrrolo[2,1-c][1,4]benzodiazepine (PBD)- polyaminoalkyl conjugates by the use of SNAr reaction of 2-nitro-5-fluorobenzoate precursor as key reaction

The design and synthesis of a series of pyrrolo[2,1-c][1,4]benzodiazepine (PBD)- polyaminoalkyl conjugates as DNA minor groove binders are described. To introduce polyaminoalkyl groups to the pyrrolo[2,1-c][1,4]benzodiazepine pharmacophore, SNA

Synthesis of polyaminoalkyl substituted conjugates of pyrrolo[2,1- c][1,4]benzodiazepine involving S(N)Ar reaction of 2-nitro-5-fluorobenzoate precursors

A synthetic procedure is described for conjugating polyaminoalkyl groups to the pyrrolo[2,1-c][1,4]benzodiazepine pharmacophore in order to alter its characteristic DNA sequence binding preference. To this end S(N)Ar reactions of 2-nitro-5-fluorobenzoate

Chemoenzymatic syntheses of two optically active hexa-azamacrocycles

Two optically active hexa-azamacrocycles with C2 and D2 symmetry, respectively, have been efficiently synthesized from the enzymatically prepared (R,R)-cyclohexane-1,2-diamine bis(amidoester) derivative (R,R)-4.