261900-37-2

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 4403-78-5 ditosylethylenediamine 
• 100-39-0 benzyl bromide 
• 174709-60-5 N,N'-bis(p-toluenesulfonyl)-N,N'-bis(3-hydroxypropyl)ethylenediamine 

Downstream Products

• 271253-09-9 C₄₅H₅₈N₄O₉S₄ 

Relevant academic research and scientific papers

Design and synthesis of pyrrolo[2,1-c][1,4]benzodiazepine (PBD)- polyaminoalkyl conjugates by the use of SNAr reaction of 2-nitro-5-fluorobenzoate precursor as key reaction

The design and synthesis of a series of pyrrolo[2,1-c][1,4]benzodiazepine (PBD)- polyaminoalkyl conjugates as DNA minor groove binders are described. To introduce polyaminoalkyl groups to the pyrrolo[2,1-c][1,4]benzodiazepine pharmacophore, SNA

Synthesis of polyaminoalkyl substituted conjugates of pyrrolo[2,1- c][1,4]benzodiazepine involving S(N)Ar reaction of 2-nitro-5-fluorobenzoate precursors

A synthetic procedure is described for conjugating polyaminoalkyl groups to the pyrrolo[2,1-c][1,4]benzodiazepine pharmacophore in order to alter its characteristic DNA sequence binding preference. To this end S(N)Ar reactions of 2-nitro-5-fluorobenzoate