17472-57-0 Usage
Uses
Used in Pharmaceutical Industry:
1-(1-Oxopropyl)aspidospermidine is used as a reactant in the preparation of various alkaloid-based pharmaceutical compounds. Its unique structure allows for the synthesis of a range of bioactive molecules with potential therapeutic applications.
Used in Organic Chemistry:
1-(1-Oxopropyl)aspidospermidine serves as an important intermediate in the synthesis of complex organic molecules. Its reactivity and structural features make it a valuable building block for the development of new compounds with diverse applications in various fields.
Used in Drug Synthesis:
1-(1-Oxopropyl)aspidospermidine is used as a key reactant in the preparation of several alkaloid-based drugs, including (+)-vincadifformine (V756988), (-)-quebrachamine, (+)-aspidospermidine (V416500), (-)-aspidospermine, and (-)-pyrifolidine. These compounds are synthesized through a series of chemical reactions, such as diastereoselective intermolecular cycloaddition, amidation cascade, and Fischer indolization, which highlight the versatility of 1-(1-Oxopropyl)aspidospermidine in drug synthesis.
Check Digit Verification of cas no
The CAS Registry Mumber 17472-57-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,4,7 and 2 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 17472-57:
(7*1)+(6*7)+(5*4)+(4*7)+(3*2)+(2*5)+(1*7)=120
120 % 10 = 0
So 17472-57-0 is a valid CAS Registry Number.
17472-57-0Relevant academic research and scientific papers
Divergent Asymmetric Total Synthesis of (+)-Vincadifformine, (-)-Quebrachamine, (+)-Aspidospermidine, (-)-Aspidospermine, (-)-Pyrifolidine, and Related Natural Products
Wang, Nengzhong,Du, Shuo,Li, Dong,Jiang, Xuefeng
, p. 3167 - 3170 (2017/06/23)
A uniformly strategic total synthesis of Aspidosperma alkaloids (+)-vincadifformine, (-)-quebrachamine, (+)-aspidospermidine, (-)-aspidospermine, (-)-pyrifolidine, and nine others from efficiently constructed tricyclic ketone 13 is reported. Highlights of these divergent and practical syntheses include (i) stereoselective intermolecular [4 + 2] cycloaddition to establish a C-E ring with one all-carbon quaternary stereocenter (C-5) and two bridged contiguous cis-stereocenters (C-12 and C-19), (ii) a Pd/C-catalyzed hydrogenation/deprotection/amidation cascade process to assemble the D ring, and (iii) Fischer indolization to forge the A-B ring.
