174729-14-7

Basic information

• Product Name: 13-O-((2S,3R)-3-bromo-2-hydroxy-3-phenylpropionyl)-7,10-O,O'-bis(2,2,2-trichloroethoxycarbonyl)-10-deacetylbaccatin
• Synonyms: 13-O-((2S,3R)-3-bromo-2-hydroxy-3-phenylpropionyl)-7,10-O,O'-bis(2,2,2-trichloroethoxycarbonyl)-10-deacetylbaccatin
• CAS NO: 174729-14-7
• Molecular Weight: 1122.45
• Mol File: 174729-14-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 13-O-((2S,3R)-3-bromo-2-hydroxy-3-phenylpropionyl)-7,10-O,O'-bis(2,2,2-trichloroethoxycarbonyl)-10-deacetylbaccatin(CAS DataBase Reference)
• NIST Chemistry Reference: 13-O-((2S,3R)-3-bromo-2-hydroxy-3-phenylpropionyl)-7,10-O,O'-bis(2,2,2-trichloroethoxycarbonyl)-10-deacetylbaccatin(174729-14-7)
• EPA Substance Registry System: 13-O-((2S,3R)-3-bromo-2-hydroxy-3-phenylpropionyl)-7,10-O,O'-bis(2,2,2-trichloroethoxycarbonyl)-10-deacetylbaccatin(174729-14-7)

Safety Data

• Hazardous Substances Data: 174729-14-7(Hazardous Substances Data)

Upstream product

• 79898-19-4 (2R,3S)-3-phenyloxiranecarboxylic acid 
• 115794-67-7 methyl (2R,3S)-3-phenylglycidate 
• 174847-58-6 C₄₄H₄₄Cl₆O₁₆ 

Downstream Products

• 222171-63-3 C₅₀H₅₀Cl₆O₁₆S 
• 174847-58-6 C₄₄H₄₄Cl₆O₁₆ 
• 174729-13-6 C₄₄H₄₅Cl₆N₃O₁₆ 
• 222171-61-1 C₄₄H₄₆Cl₆O₁₆S 
• 222174-78-9 7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)-3'-epi-docetaxel 
• 222171-69-9 C₄₉H₅₅Cl₆NO₁₇S 
• 222171-67-7 C₄₉H₅₄Cl₆O₁₇S 
• 222171-66-6 C₄₄H₄₅Cl₆N₃O₁₆ 
• 222171-64-4 C₄₄H₄₈O₁₂S 
• 114915-14-9 7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel 
• 114915-20-7 Docetaxel 

Relevant articles and documents

Regio- and stereoselective methods for the conversion of (2S,3R)-β-phenylglycidic acid esters to taxoids and other enantiopure (2R,3S)-phenylisoserine esters

A novel efficient method was proposed for the synthesis of enantiopure precursors of taxane-containing cytostatics, i.e., methyl esters of (2R,3S)- and (2S,3R)-N-benzoylphenylisoserine and similar taxoid esters. The method is based on the regio- and stereoselective hydrobromolysis of the corresponding trans-β-phenyl glycidate enatiomers, consecutive reactions of O-acylcarbamoylation of the obtained 3-bromohydrins, intramolecular cyclization to 4-phenyloxazolidin-2-one-5-carboxylic acid derivatives, and oxazolidinone ring opening.