174729-95-4

Upstream product

• 116-11-0 2-Methoxypropene 
• 174729-94-3 methyl (2R,3S)-3-(2,4-difluorophenyl)-3-tert-butoxycarbonylamino-2-hydroxypropionate 
• 186758-21-4 methyl (2E)-3-(2,4-difluorophenyl)prop-2-enoate 
• 186758-22-5 (2R,3S)-3-(2,4-Difluoro-phenyl)-2,3-dihydroxy-propionic acid methyl ester 
• 186758-15-6 (2R,3S)-2-Acetoxy-3-azido-3-(2,4-difluoro-phenyl)-propionic acid methyl ester 
• 174729-93-2 methyl (2R,3S)-3-(2,4-difluorophenyl)-3-azido-2-hydroxypropionate 
• 186758-24-7 (2S,3R)-2-Acetoxy-3-bromo-3-(2,4-difluoro-phenyl)-propionic acid methyl ester 
• 186758-23-6 (4R,5S)-5-(2,4-Difluoro-phenyl)-2-methoxy-2-methyl-[1,3]dioxolane-4-carboxylic acid methyl ester 

Downstream Products

• 174729-96-5 (4S,5R)-3-tert-butoxycarbonyl-2,2-dimethyl-4-(2,4-difluorophenyl)-5-oxazolidinecarboxylic acid 

Relevant academic research and scientific papers

Synthesis of taxoids I. Regioselective Lewis acid-mediated ring-opening of aryl orthoacetates

The reaction of aryl orthoacetates with acetyl bromide readily proceeded regioselectively to afford the desirable aryl bromides in the presence of tin(II) or zinc bromide as a catalyst. The synthesis of some docetaxel derivatives is also described by using this improved process.

Baccatin derivatives and processes for preparing the same

Disclosed are 13α-(3-substituted-2-hydroxypropionyloxy)baccatin compounds represented by the formula: STR1 wherein R1 represents a lower alkanoyl group or a protective group for hydroxy group; R2 represents a protective group for hyd