17473-79-9

Basic information

• Product Name: Benzoic acid,2-(1,1-dimethylethyl)hydrazide
• Synonyms: Benzoicacid, 2-tert-butylhydrazide (8CI); 1-Benzoyl-2-tert-butylhydrazine;N-Benzoyl-N'-tert-butylhydrazine; NSC 172377; N'-tert-Butyl-N-benzoylhydrazine
• CAS NO: 17473-79-9
• Molecular Formula: C11H16 N2 O
• Molecular Weight: 192.261
• Mol File: 17473-79-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 258.3°Cat760mmHg
• Flash Point: 91.3°C
• Density: 1.021g/cm³
• CAS DataBase Reference: Benzoic acid,2-(1,1-dimethylethyl)hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid,2-(1,1-dimethylethyl)hydrazide(17473-79-9)
• EPA Substance Registry System: Benzoic acid,2-(1,1-dimethylethyl)hydrazide(17473-79-9)

Safety Data

• Hazardous Substances Data: 17473-79-9(Hazardous Substances Data)

Upstream product

• 7400-27-3 tertbutylhydrazine hydrochloride 
• 98-88-4 benzoyl chloride 

Downstream Products

• 112225-83-9 2-benzoyl-1-tert-butyl-1-(m-chlorobenzoyl)hydrazine 
• 112226-58-1 N'-tert-butyl-N-benzoyl-N'-(2-chlorobenzoyl)hydrazine 
• 112225-87-3 benzoic acid N'-benzoyl-N-tert-butylhydrazide 
• 112226-54-7 N-Benzoyl-N'-(4-chlorobenzoyl)-N'-tert-butylhydrazine 
• 112226-92-3 N'-t-butyl-N-benzoyl-N'-(4-anisoyl)hydrazine 
• 67523-85-7 N'-t-butyl-N-benzoyl-N'-(4-nitrobenzoyl)hydrazine 
• 112226-77-4 N'-t-butyl-N-benzoyl-N'-(2-methoxybenzoyl)hydrazine 
• 112226-97-8 N'-t-butyl-N-benzoyl-N'-(2,4-dichlorobenzoyl)hydrazine 

Relevant articles and documents

Synthesis of 3 H-1,2,4-Triazol-3-ones via NiCl2-Promoted Cascade Annulation of Hydrazonoyl Chlorides and Sodium Cyanate

A nickel-promoted cascade annulation reaction for the facile synthesis of 3H-1,2,4-triazol-3-ones from readily available hydrazonoyl chlorides and sodium cyanate has been developed. The transformation occurs through a cascade nickel-promoted intermolecular nucleophilic addition-elimination process, intramolecular nucleophilic addition, and a hydrogen-transfer sequence. The method has been successfully applied for the construction of the core skeleton of the angiotensin II antagonist.

Synthesis and insecticidal activity of chromanone and chromone analogues of diacylhydrazines

Diacylhydrazine derivatives have been identified as one of the most important insect growth regulators. A variety of diacylhydrazine derivatives were designed and synthesized in recent years due to their unique action mechanism, simple structure, and environmental benign character. This paper describes the molecular design, synthesis, and insecticidal activities of a series of chromanone and chromone analogues of diacylhydrazine derivatives. The preliminary bioassay showed that some of the chromanone analogues exhibited good insecticidal activity against Mythima separata at the dosage of 500 mg L-1. The present work demonstrated that replacement of the chroman ring of ANS-118, a commercial insecticide, with chromanone moiety could result in new compounds with high potent insecticidal activity.

A novel convenient synthesis of 1,3,4-oxadiazol-2-ones and -thiones from N-tert-butyldiacylhydrazines

An attractive, novel, convenient process for the preparation of 3,5-disubstituted-3H-[1,3,4]-oxadiazol-2-ones and -thiones from the reaction of various equivalent and non-equivalent N-tertbutyldiacylhydrazines with potassium tert-butoxide followed by treatment with phosgene or thiophosgene, respectively, has been discovered. The 3,5-disubstituted-3H-[1,3,4]-oxadiazol-2-ones and -thiones are confirmed both analytically and chemically. Various equivalent and non-equivalent N-tert-butyldiacylhydrazines are conveniently synthesized from the reaction of tert-butylhydrazine hydrochloride in the presence of i-Pr2NEt, with acid chloride #1 followed by subsequent treatment with acid chloride #2. Both the syntheses of 3,5-disubstituted-3H-[1,3,4]-oxadiazol-2-ones and -thiones, as well as N-tert-butyldiacylhydrazines, are easily performed on multigram scales.