17473-79-9

Upstream product

• 7400-27-3 tertbutylhydrazine hydrochloride 
• 98-88-4 benzoyl chloride 

Downstream Products

• 112225-87-3 benzoic acid N'-benzoyl-N-tert-butylhydrazide 
• 112226-54-7 N-Benzoyl-N'-(4-chlorobenzoyl)-N'-tert-butylhydrazine 
• 112226-92-3 N'-t-butyl-N-benzoyl-N'-(4-anisoyl)hydrazine 

Relevant academic research and scientific papers

Synthesis of 3 H-1,2,4-Triazol-3-ones via NiCl2-Promoted Cascade Annulation of Hydrazonoyl Chlorides and Sodium Cyanate

A nickel-promoted cascade annulation reaction for the facile synthesis of 3H-1,2,4-triazol-3-ones from readily available hydrazonoyl chlorides and sodium cyanate has been developed. The transformation occurs through a cascade nickel-promoted intermolecular nucleophilic addition-elimination process, intramolecular nucleophilic addition, and a hydrogen-transfer sequence. The method has been successfully applied for the construction of the core skeleton of the angiotensin II antagonist.

Pd-catalyzed oxidative annulation of hydrazides with isocyanides: Synthesis of 2-amino-1,3,4-oxadiazoles

An efficient palladium-catalyzed oxidative annulation reaction was developed through sequential isocyanide insertions into N-H and O-H bonds of hydrazides, which provides an efficient access to valuable 2-amino-1,3,4- oxadiazoles and their derivatives.

Synthesis and insecticidal activity of chromanone and chromone analogues of diacylhydrazines

Diacylhydrazine derivatives have been identified as one of the most important insect growth regulators. A variety of diacylhydrazine derivatives were designed and synthesized in recent years due to their unique action mechanism, simple structure, and environmental benign character. This paper describes the molecular design, synthesis, and insecticidal activities of a series of chromanone and chromone analogues of diacylhydrazine derivatives. The preliminary bioassay showed that some of the chromanone analogues exhibited good insecticidal activity against Mythima separata at the dosage of 500 mg L-1. The present work demonstrated that replacement of the chroman ring of ANS-118, a commercial insecticide, with chromanone moiety could result in new compounds with high potent insecticidal activity.

Alkylgermasesquioxide Derivatives of tert-Butyl-diacylhydrazines

N-tert-Butyl-N-benzoylhydrazine was synthesized by a new method. Its condensation and the condensation of its N,N'-isomer with 3-(trichlorogermyl)propionyl chloride provided N-tert-butyl-N'-(3-trichlorogermyl)propionyl-N-benzoylhydrazine or its N,N,N'-isomer, respectively, in good yields. Subsequent hydrolysis of the trichlorogermyl compounds using saturated sodium carbonate yielded the corresponding germasesquioxide derivatives that have good solubility in organic solvents. The structures of these compounds were confirmed by 1H NMR, IR, MS, and elemental analysis. The hydrolysis of organogermanium trichloride was studied, and the elimination of HGeCl3 was observed when the basicity was too high (pH>10).

A novel convenient synthesis of 1,3,4-oxadiazol-2-ones and -thiones from N-tert-butyldiacylhydrazines

An attractive, novel, convenient process for the preparation of 3,5-disubstituted-3H-[1,3,4]-oxadiazol-2-ones and -thiones from the reaction of various equivalent and non-equivalent N-tertbutyldiacylhydrazines with potassium tert-butoxide followed by treatment with phosgene or thiophosgene, respectively, has been discovered. The 3,5-disubstituted-3H-[1,3,4]-oxadiazol-2-ones and -thiones are confirmed both analytically and chemically. Various equivalent and non-equivalent N-tert-butyldiacylhydrazines are conveniently synthesized from the reaction of tert-butylhydrazine hydrochloride in the presence of i-Pr2NEt, with acid chloride #1 followed by subsequent treatment with acid chloride #2. Both the syntheses of 3,5-disubstituted-3H-[1,3,4]-oxadiazol-2-ones and -thiones, as well as N-tert-butyldiacylhydrazines, are easily performed on multigram scales.

Insecticidal ferrocenoyl acylhydrazines

Insecticidal compounds of the formula STR1 wherein one of A or B is ferrocenyl and the other of A or B is phenyl or substituted phenyl and R is branched alkyl are effective in controlling the Southern Armyworm and Mexican Bean Beetle.

Unsymmetrical tertiary-aliphatic azoalkanes

Unsymmetrical azo compounds (R")3 C--N=N--R' where (R")3 C-- is tert.-aliphatic and R' is --C(R1)(R2)(Z) or STR1 e.g., 1-t-butylazo-1-chlorocyclohexane, their use as vinyl polymerization initiators and polyester resin curing agents, and methods for preparing same from t-aliphatic hydrazones and t-aliphatic α-halo-substituted azoalkanes.