174732-83-3

Upstream product

• 659-28-9 p-trifluoromethoxybenzaldehyde 
• 174732-78-6 C₁₃H₁₂F₃NO₄ 

Downstream Products

• 921605-11-0 2-({(2S)-2-amino-3-[4-(trifluoromethoxy)phenyl]propanoyl}amino)ethyl acetate 
• 921609-34-9 (2S)-2-amino-3-[4-(trifluoromethoxy)phenyl]propanoic acid hydrochloride 
• 174732-77-5 2-amino-3-[4-(trifluoromethoxy)phenyl]propanoic acid hydrochloride 
• 921623-42-9 methyl (2S)-2-(acetylamino)-3-[4-(trifluoromethoxy)phenyl]propanoate 

Relevant academic research and scientific papers

USP30 INHIBITORS

The application relates to phenyl- or naphthylsulfonamide derivatives of the structural formula (I). The compounds are described as inhibitors of USP30 (ubiquitin specific peptidase 30) useful for the treatment of conditions involving mitochondrial defects including neurodegenerative diseases such as Alzheimer's and Parkinson's or a neoplastic disease such as leukemia.

SUBSTITUTED PROPANAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

It is an object of the present invention to provide a substituted propanamide derivative or a pharmacologically acceptable salt thereof that is useful as a prophylactic or therapeutic agent for a bone metabolic disease. The present invention relates to a pharmaceutical composition comprising a compound having General Formula (I) or a pharmacologically acceptable salt thereof as an active ingredient: [wherein, R1 represents a C6-C10 aryl group that may be substituted by a group selected from Substituent Group α, for example; R2 represents a C6-C10aryl group that may be substituted by a group selected from Substituent Group α, for example; and X represents a hydroxyl group or a C1-C6 alkoxy group, for example].