174732-78-6

Basic information

• Product Name: C₁₃H₁₂F₃NO₄
• Synonyms: C₁₃H₁₂F₃NO₄
• CAS NO: 174732-78-6
• Molecular Weight: 303.238
• Mol File: 174732-78-6.mol

Chemical Properties

• CAS DataBase Reference: C₁₃H₁₂F₃NO₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₁₂F₃NO₄(174732-78-6)
• EPA Substance Registry System: C₁₃H₁₂F₃NO₄(174732-78-6)

Safety Data

• Hazardous Substances Data: 174732-78-6(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 659-28-9 p-trifluoromethoxybenzaldehyde 
• 7087-68-5 N-ethyl-N,N-diisopropylamine 

Downstream Products

• 921623-42-9 methyl (2S)-2-(acetylamino)-3-[4-(trifluoromethoxy)phenyl]propanoate 
• 921609-34-9 (2S)-2-amino-3-[4-(trifluoromethoxy)phenyl]propanoic acid hydrochloride 
• 174732-77-5 2-amino-3-[4-(trifluoromethoxy)phenyl]propanoic acid hydrochloride 
• 174732-83-3 Methyl 2-(acetylamino)-3-[4-(trifluoromethoxy)phenyl]propanoate 

Relevant articles and documents

USP30 INHIBITORS

The application relates to phenyl- or naphthylsulfonamide derivatives of the structural formula (I). The compounds are described as inhibitors of USP30 (ubiquitin specific peptidase 30) useful for the treatment of conditions involving mitochondrial defects including neurodegenerative diseases such as Alzheimer's and Parkinson's or a neoplastic disease such as leukemia.

SUBSTITUTED PROPANAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

It is an object of the present invention to provide a substituted propanamide derivative or a pharmacologically acceptable salt thereof that is useful as a prophylactic or therapeutic agent for a bone metabolic disease. The present invention relates to a pharmaceutical composition comprising a compound having General Formula (I) or a pharmacologically acceptable salt thereof as an active ingredient: [wherein, R1 represents a C6-C10 aryl group that may be substituted by a group selected from Substituent Group α, for example; R2 represents a C6-C10aryl group that may be substituted by a group selected from Substituent Group α, for example; and X represents a hydroxyl group or a C1-C6 alkoxy group, for example].