174787-75-8

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 174787-60-1 (4S,5S)-5-ethenyl-4-phenyl-1,3-oxazolidin-2-one 
• 174787-57-6 (4S,5S)-5-(2-hydroxy)ethyl-4-phenyl-2-oxazolidinone 
• 100-58-3 phenylmagnesium bromide 

Downstream Products

• 479078-61-0 (4S,5R)-2-Oxo-4-phenyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 
• 143615-03-6 (4S,5R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid 
• 136693-03-3 (+)-1,1-dimethylethyl (N-((1S,2S)-2-hydroxy-1-phenyl-3-butenyl)amino)methanoate 

Relevant academic research and scientific papers

Lipase-catalyzed transesterification of methyl 2-substituted 3-hydroxy-4-pentenoates and its synthetic application to the taxol side chain

Syn-and anti-methyl 2-substituted 3-hydroxy-4-pentenoates were efficiently resolved in lipase-catalyzed transesterification. This protocol was successfully applied to the synthesis of the taxol side chain.

Synthetic application of chiral 4-methoxy-2-oxazolidinone synthons to 2-amino alcohols of biological interest

The versatility as chiral synthons of (4S, 5S)- and (4R, 5R)-5-allyl-4-methoxy-2-oxazolidinones, readily obtainable from 3-[(1S)-2-exo-alkoxy-1-apocamphanecarbonyl]-2-oxazolone, is demonstrated by the facile stereospecific conversions to (2R, 3S)-3-amino-2-hydroxy-3-phenylpentanoic acid, (2R, 3R, 5E, 7E)-2-amino-5,7-tetradecadien-3-ol and (2S, 3R)-dihydrosphingosine.