136693-03-3Relevant articles and documents
Economical route for oxidative cleavage of double bond to synthesize taxol side chain
Bhatia, Sumati,Singh, Sukhdev,Kumar, Rajesh,Kumar, Amit,Olsen, Carl E.,Prasad, Ashok K.
, p. 379 - 386 (2013/05/08)
An efficient, economical and industry-friendly methodology has been developed for the synthesis of C-13 side chain of taxol, (2R,3S)-3-benzamido-2- hydroxy-3-phenylpropanoic acid by oxidative cleavage of alkene precursor N-[(1S,2S)-2-(1′-ethoxyethoxy)-1-p
Stereoselective synthesis of L-733,060
Bhaskar,Rao, B. Venkateswara
, p. 915 - 917 (2007/10/03)
Enantioselective synthesis of non-peptidic neurokinin NK1 receptor antagonist L-733,060 is described using ring-closing metathesis as a key step, starting from L-phenylglycine.
Synthetic application of chiral 4-methoxy-2-oxazolidinone synthons to 2-amino alcohols of biological interest
Ishizuka, Tadao,Morooka, Kohei,Ishibuchi, Seigo,Kunieda, Takehisa
, p. 837 - 848 (2007/10/03)
The versatility as chiral synthons of (4S, 5S)- and (4R, 5R)-5-allyl-4-methoxy-2-oxazolidinones, readily obtainable from 3-[(1S)-2-exo-alkoxy-1-apocamphanecarbonyl]-2-oxazolone, is demonstrated by the facile stereospecific conversions to (2R, 3S)-3-amino-2-hydroxy-3-phenylpentanoic acid, (2R, 3R, 5E, 7E)-2-amino-5,7-tetradecadien-3-ol and (2S, 3R)-dihydrosphingosine.