136693-03-3

Upstream product

• 108-22-5 Isopropenyl acetate 
• 136693-03-3 (+/-)-1,1-dimethylethyl amino>methanoate 
• 1826-67-1 vinyl magnesium bromide 
• 163061-19-6 (2S)-2-tert-butoxycarbonylamino-2-phenylacetaldehyde 
• 136693-04-4 N-[(1S,2S)-2-(1-ethoxyethoxy)-1-phenylbut-3-en-1-yl]benzamide 
• 20989-17-7 (2S)-2-phenylglycinol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 174787-57-6 (4S,5S)-5-(2-hydroxy)ethyl-4-phenyl-2-oxazolidinone 
• 174787-60-1 (4S,5S)-5-ethenyl-4-phenyl-1,3-oxazolidin-2-one 
• 143978-88-5 N-tert-butoxycarbonyl-L-phenylglycine methyl ester 
• 6591-61-3 (S)-Phenylglycine methyl ester 
• 2935-35-5 (S)-2-phenylglycine 
• 117049-14-6 tert-butyl N-[(1S)-2-hydroxy-1-phenylethyl]carbamate 
• 174787-75-8 (4S,5S)-3-tert-butoxycarbonyl-4-phenyl-5-vinyl-2-oxazolidinone 

Downstream Products

• 174787-61-2 (4S,5S)-3-tert-butoxycarbonyl-2,2-dimethyl-4-phenyl-5-vinyloxazolidine 
• 599156-26-0 [2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-but-3-enyl]-carbamic acid tert-butyl ester 
• 654639-86-8 Benzoic acid (S)-1-((S)-tert-butoxycarbonylamino-phenyl-methyl)-allyl ester 
• 143615-03-6 (4S,5R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid 
• 599156-27-1 allyl-[2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-but-3-enyl]-carbamic acid tert-butyl ester 
• 599156-28-2 tert-butyl N-[(1S,2S)-2-hydroxy-1-phenylbut-3-en-1-yl]-N-(prop-2-en-1-yl)carbamate 
• 599156-29-3 (2S,3S)-3-hydroxy-2-phenylpiperidine-1-carboxylic acid tert-butyl ester 
• 136693-05-5 1,1-dimethylethyl (N-((1S,2S)-2-(1-ethoxyethoxy)-1-phenyl-3-butenyl)amino)methanoate 
• 145433-71-2 (2R,3S)-(+)-3-<amino>-3-phenyl-2-(2,2,2-trichloroethoxy)methoxypropanoic acid 
• 145433-71-2 (2S,3R)-(+)-3-<amino>-3-phenyl-2-(2,2,2-trichloroethoxy)methoxypropanoic acid 
• 145433-73-4 (2R,3S)-(+)-3-<amino>-3-phenyl-2-(2,2,2-trichloroethoxy)methoxypropanoic acid methyl ester 
• 136693-05-5 [(1S,2S)-2-(1-Ethoxy-ethoxy)-1-phenyl-but-3-enyl]-carbamic acid tert-butyl ester 
• 145433-72-3 [(1S,2S)-1-Phenyl-2-(2,2,2-trichloro-ethoxymethoxy)-but-3-enyl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Economical route for oxidative cleavage of double bond to synthesize taxol side chain

An efficient, economical and industry-friendly methodology has been developed for the synthesis of C-13 side chain of taxol, (2R,3S)-3-benzamido-2- hydroxy-3-phenylpropanoic acid by oxidative cleavage of alkene precursor N-[(1S,2S)-2-(1′-ethoxyethoxy)-1-p

PROCESS FOR PREPARING OXAZOLIDINE DERIVATIVES

A process for preparing (4S,5R)-5-carboxymethyl-2,2-dimethyl-4-phenyl-oxazolidine-3-carboxylic acid t-butyl ester, an intermediate in the preparation of anticancer compounds having a taxane skeleton, such as paclitaxel, docetaxol, etc.

Lipase-Catalyzed Kinetic Resolution of 4-(N-Boc-amino)-1-alken-3-ols

A wide range of 4-(N-Boc-amino)-1-alken-3-ols were efficiently resolved by lipase-catalyzed kinetic resolution. This procedure has been successfully applied to the highly enantioselective synthesis of the taxol side chain.

Stereoselective synthesis of L-733,060

Enantioselective synthesis of non-peptidic neurokinin NK1 receptor antagonist L-733,060 is described using ring-closing metathesis as a key step, starting from L-phenylglycine.

Synthetic application of chiral 4-methoxy-2-oxazolidinone synthons to 2-amino alcohols of biological interest

The versatility as chiral synthons of (4S, 5S)- and (4R, 5R)-5-allyl-4-methoxy-2-oxazolidinones, readily obtainable from 3-[(1S)-2-exo-alkoxy-1-apocamphanecarbonyl]-2-oxazolone, is demonstrated by the facile stereospecific conversions to (2R, 3S)-3-amino-2-hydroxy-3-phenylpentanoic acid, (2R, 3R, 5E, 7E)-2-amino-5,7-tetradecadien-3-ol and (2S, 3R)-dihydrosphingosine.

Stereoselective vinylation of amino aldehydes using 2-trimethylsilylethylidentriphenylphosphorane

2-Trimethylsilylethylidentriphenylphosphorane reacts stereoselectively with α-amino aldehydes giving the Cram chelation controlled product of vinylation of the carbonyl group. The olefinic 1,2-amino alcohols obtained with this reaction are important inter