174824-48-7

Upstream product

• 5617-70-9 cycl-isopropylidene cyclopropane-1,1-dicarboxylate 
• 98-16-8 3-trifluoromethylaniline 
• 38348-84-4 1-(3-(trifluoromethyl)phenyl)pyrrolidin-2-one 
• 616-38-6 carbonic acid dimethyl ester 

Downstream Products

• 1188542-34-8 8-{1-[2-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1,3-dipropyl-3,7-dihydropurine-2,6-dione 
• 1188542-37-1 8-{1-[2-oxo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1,3-dipropyl-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione 
• 1188542-36-0 methanesulfonic acid 2-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-ylmethyl ester 

Relevant academic research and scientific papers

A2Badenosine receptor antagonists: Design, synthesis and biological evaluation of novel xanthine derivatives

A2BAdoR is a low affinity adenosine receptor that functions by Gs mediated elevation of cAMP and subsequent downstream signaling. The receptor has been implicated in lung inflammatory disorders like?COPD and asthma. Several potent and selective

HETEROCYCLIC COMPOUNDS AS ADENOSINE RECEPTOR ANTAGONIST

Compounds of the present disclosure are fused pyrimidine compounds of formula (I), its tautomers, polymorphs, stereoisomers, prodrugs, solvate or a pharmaceutically acceptable salts thereof, as Adenosine receptor antagonists. Processes of their preparation are also described in the disclosure.

1-PHENYLPYRROLIDINE-2-ONE-3-CARBOXAMIDES

The invention relates to 1-phenylpyrrolidine-2-one-3-carboxamides of general formula (I), wherein variables R1, R2, R3, X, Y, A, n, Ra, Rb, Rc, Rd and Re have the meanings as cited in Claim 1, and to agriculturally usable salts thereof. The invention also relates to: the use of compounds I and/or the salts thereof as herbicides; plant protection products containing, as active substances, at least one 1-phenylpyrrolidine-2-one-3-carboxamide of formula (I) and/or at least one agriculturally usable salt of formula (I), and; a method for controlling unwanted plant growth during which a herbicidally effective amount of at least one 1-phenylpyrrolidine-2-one-3-carboxamide of formula (I) or of an agriculturally usable salt of formula (I) is permitted to act upon plants, the habitat thereof or upon seeds.

Method for production of pyrrolidinone derivatives

A compound represented by the following formula (12) useful as an intermediate for production of drug or agricultural chemical: (wherein R21to R25are each independently a hydrogen atom, a hydroxyl group, a halogen atom, an alkyl grou

Herbicidally active phenylsubstituted 5-and 6-membered heterocyclic compounds

A compound of formula (I): STR1 where E is oxygen or sulphur; A is CR3 or N where R3 is hydrogen or hydrocarbyl; D completes a 5 or 6-membered non-aromatic heterocyclic ring which optionally contains additional heteroatoms selected from oxygen, nitrogen or sulphur and which is optionally substituted by an optionally substituted lower hydrocarbyl group, or an optionally substituted heteroaryl group; R1 and R2 are each independently hydrogen; optionally substituted lower hydrocarbyl, or optionally substituted heteroaryl, or R1 and R2 together with the nitrogen atom to which they are attached, form a heterocyclic ring; Z represents halogen optionally substituted lower hydrocarbyl, optionally substituted lower hydocarbyloxy, optionally substituted lower hydrocarbylthio, hydrocarbylsulphinyl or hydrocarbylsulphonyl, cyano, nitro, CHO, NHOH, ONR7' R7", SF5 ; CO (optionally substituted lower hydrocarbyl), acylamino, COOR7, SO2 NR8 R9, CONR10 R11, OR12 or NR13 R14 where R7, R7', R7", R8, R9, R10 and R11 are independently hydrogen or lower hydrocarbyl; R12 is hydrogen; SO2 lower hydrocarbyl or COR15 ; R13 and R14 are independently lower hydrocarbyl, lower hydrocarbyloxy or a group R12 ; R15 is OR16, NR17 R18, hydrogen or lower hydrocarbyl; R16 is lower hydrocarbyl; R17 and R18 are independently hydrogen or lower hydrocarbyl; provided that when there are two or more substituents Z, they may be the same or different; and m is 0 or an integer from 1 to 5.

Pyrrolidine-2-thione derivatives as herbicides

Pyrrolidine-2-thione derivatives of the formula (I) STR1 wherein the variables are as defined in the specification are active as herbicides.

Process for preparing pyrrolidinones

A process for the preparation of a compound of general formula II: STR1 wherein R1 is hydrogen, or C1 -C10 hydrocarbyl or heterocyclyl having 3 to 8 ring atoms, either of which may optionally be substituted; each R2, R3, R4 and R5 is independently hydrogen or C1 -C4 alkyl; A is an optionally substituted aromatic or heteroaromatic ring system; and R21 is hydrogen, halogen, OH or OCONHR1, wherein R1 is as defined above; the process comprising cyclizing a compound of general formula III: STR2 wherein A, R2, R3, R4, R5 and R21 are as defined in general formula II and R25 is a leaving group such as a halogen atom; under basic conditions.