38348-84-4

Usage

Uses

Used in Pharmaceutical Research and Development:
1-(3-(trifluoromethyl)phenyl)pyrrolidin-2-one is utilized as a building block in the synthesis of various pharmaceutical agents and drug candidates. Its unique structure and properties make it a valuable component in the development of new medications.
Used in Agrochemical Research:
Due to its distinctive chemical structure and properties, 1-(3-(trifluoromethyl)phenyl)pyrrolidin-2-one may also have potential applications in the field of agrochemical research, where it could contribute to the development of novel compounds for agricultural purposes.
Used in Material Science Research:
The unique properties of 1-(3-(trifluoromethyl)phenyl)pyrrolidin-2-one also suggest potential uses in material science research, where it could be explored for the creation of new materials with specific characteristics.

Upstream product

• 96-48-0 4-butanolide 
• 98-16-8 3-trifluoromethylaniline 
• 616-45-5 2-pyrrolidinon 
• 401-81-0 m-trifluoromethylphenyl iodide 

Downstream Products

• 174824-47-6 3-hydroxy-1-(3-trifluoromethyl)phenyl-2-pyrrolidinone 
• 174824-48-7 2-oxo-1-(3-trifluoromethylphenyl)pyrrolidine-3-carboxylic acid 

Relevant academic research and scientific papers

Efficient ligand-free copper-catalyzed N-arylation of amides with aryl halides in water

A convenient and efficient protocol has been developed for the cross-coupling of amides and aryl iodides using a ligand-free copper(I) oxide catalyst in water. A variety of amide derivatives afforded the corresponding N-arylated products in moderate to good yields (up to 88%).

Mild and Efficient Cobalt-Catalyzed Cross-Coupling of Aliphatic Amides and Aryl Iodides in Water

A convenient protocol for the C-N cross-coupling of aliphatic amides and iodobenzene is demonstrated using a simple and inexpensive Co(C2O4)·2H2O/N,N′-dimethylethylenediamine (DMEDA) catalytic system in water. Good yields of N-arylated products were isolated (up to 85%) and the protocol has been successfully applied to the synthesis of the anticancer drug, flutamide.

1-PHENYLPYRROLIDINE-2-ONE-3-CARBOXAMIDES

The invention relates to 1-phenylpyrrolidine-2-one-3-carboxamides of general formula (I), wherein variables R1, R2, R3, X, Y, A, n, Ra, Rb, Rc, Rd and Re have the meanings as cited in Claim 1, and to agriculturally usable salts thereof. The invention also relates to: the use of compounds I and/or the salts thereof as herbicides; plant protection products containing, as active substances, at least one 1-phenylpyrrolidine-2-one-3-carboxamide of formula (I) and/or at least one agriculturally usable salt of formula (I), and; a method for controlling unwanted plant growth during which a herbicidally effective amount of at least one 1-phenylpyrrolidine-2-one-3-carboxamide of formula (I) or of an agriculturally usable salt of formula (I) is permitted to act upon plants, the habitat thereof or upon seeds.

Herbicidally active phenylsubstituted 5-and 6-membered heterocyclic compounds

A compound of formula (I): STR1 where E is oxygen or sulphur; A is CR3 or N where R3 is hydrogen or hydrocarbyl; D completes a 5 or 6-membered non-aromatic heterocyclic ring which optionally contains additional heteroatoms selected from oxygen, nitrogen or sulphur and which is optionally substituted by an optionally substituted lower hydrocarbyl group, or an optionally substituted heteroaryl group; R1 and R2 are each independently hydrogen; optionally substituted lower hydrocarbyl, or optionally substituted heteroaryl, or R1 and R2 together with the nitrogen atom to which they are attached, form a heterocyclic ring; Z represents halogen optionally substituted lower hydrocarbyl, optionally substituted lower hydocarbyloxy, optionally substituted lower hydrocarbylthio, hydrocarbylsulphinyl or hydrocarbylsulphonyl, cyano, nitro, CHO, NHOH, ONR7' R7", SF5 ; CO (optionally substituted lower hydrocarbyl), acylamino, COOR7, SO2 NR8 R9, CONR10 R11, OR12 or NR13 R14 where R7, R7', R7", R8, R9, R10 and R11 are independently hydrogen or lower hydrocarbyl; R12 is hydrogen; SO2 lower hydrocarbyl or COR15 ; R13 and R14 are independently lower hydrocarbyl, lower hydrocarbyloxy or a group R12 ; R15 is OR16, NR17 R18, hydrogen or lower hydrocarbyl; R16 is lower hydrocarbyl; R17 and R18 are independently hydrogen or lower hydrocarbyl; provided that when there are two or more substituents Z, they may be the same or different; and m is 0 or an integer from 1 to 5.

Pyrrolidine-2-thione derivatives as herbicides

Pyrrolidine-2-thione derivatives of the formula (I) STR1 wherein the variables are as defined in the specification are active as herbicides.

Process for preparing pyrrolidinones

A process for the preparation of a compound of general formula II: STR1 wherein R1 is hydrogen, or C1 -C10 hydrocarbyl or heterocyclyl having 3 to 8 ring atoms, either of which may optionally be substituted; each R2, R3, R4 and R5 is independently hydrogen or C1 -C4 alkyl; A is an optionally substituted aromatic or heteroaromatic ring system; and R21 is hydrogen, halogen, OH or OCONHR1, wherein R1 is as defined above; the process comprising cyclizing a compound of general formula III: STR2 wherein A, R2, R3, R4, R5 and R21 are as defined in general formula II and R25 is a leaving group such as a halogen atom; under basic conditions.

N-Substituted pyrrolidones and their use as miticides

Compounds having the formula STR1 in which R1 is C1 -C4 alkyl, R2 is selected from the group consisting of hydrogen and --CH2 X in which X is halogen, and R3 is selected from the group consisting of allyl and STR2 in which Y is selected from the group consisting of halogen and trifluoromethyl and their use as miticides are disclosed herein.