174833-91-1Relevant academic research and scientific papers
Applications of pentafluorophenylester coupling in the synthesis of cyclodepsipeptides related to valinomycins
Dory, Yves L.,Mellor, John M.,McAleer, Jerome F.
, p. 1343 - 1360 (1996)
A number of strategies of synthesis of cyclic depsipeptides are examined including cyclisation protocols based on pentafluorophenyl esters. The alternatives of amine protection as benzyloxycarbonyl or t-butoxycarbonyl derivatives are examined and optimum
Total synthesis of grassystatin A, a probe for cathepsin e function
Yang, Siming,Zhang, Wei,Ding, Ning,Lo, Jeannette,Liu, Yanxia,Clare-Salzler, Michael J.,Luesch, Hendrik,Li, Yingxia
experimental part, p. 4774 - 4780 (2012/09/08)
The linear depsipeptide grassystatin A, a valuable probe for the study of cathepsin E function, has been synthesized by a [4+6] strategy. It exhibited specific inhibitory activity against cathepsin E with an IC50 value of 0.8 nM. Our studies in
