174840-02-9Relevant articles and documents
IOOC route to substituted chiral pyrrolidines. Potential glycosidase inhibitors
Falb, Eliezer,Bechor, Yosi,Nudelman, Abraham,Hassner, Alfred,Albeck, Amnon,Gottlieb, Hugo E.
, p. 498 - 506 (2007/10/03)
Branched-chain five-membered ring aza-sugar analogues, synthesized from amino acids by an intramolecular oxime-olefin cycloaddition reaction, the IOOC route, were found to be selective glycosidase inhibitors. The derivative 2,4(S)-di(hydroxymethyl)-3(S)-aminopyrrolidine, obtained from D-serine, was about 1 order of potency more active than its enantiomer obtained from L- serine.