174844-42-9 Usage
General Description
2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)aMino]-2-deoxy-D-glucose, also known as 2-NBDG, is a fluorescent glucose analog commonly used as a glucose uptake marker in cell biology and metabolic studies. It is a non-metabolizable derivative of glucose that can be taken up by cells through glucose transporters and detected using fluorescence microscopy or flow cytometry. Its fluorescence properties make it a valuable tool for studying glucose transport and metabolism in various cell types, including cancer cells, adipocytes, and muscle cells. Additionally, 2-NBDG has been used in a wide range of research applications, including cancer research, diabetes studies, and exercise physiology.
Check Digit Verification of cas no
The CAS Registry Mumber 174844-42-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,4,8,4 and 4 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 174844-42:
(8*1)+(7*7)+(6*4)+(5*8)+(4*4)+(3*4)+(2*4)+(1*2)=159
159 % 10 = 9
So 174844-42-9 is a valid CAS Registry Number.
174844-42-9Relevant articles and documents
Improved synthesis of 4-amino-7-nitrobenz-2,1,3-oxadiazoles using NBD fluoride (NBD-F)
Jung, Michael E.,Dong, Timothy A.,Cai, Xiaolu
, p. 2533 - 2535 (2011/06/21)
The 7-nitrobenz-2,1,3-oxadiazole (NBD) unit is a highly useful fluorescent tag with wide application in biology. Installation of the NBD group typically proceeds via the SNAr reaction between an amine and an NBD halide. Herein, we demonstrate that NBD-F 1 results in significantly higher yields than NBD-Cl 2, and that triethylamine in dimethylformamide at 23 °C overnight is a broadly applicable set of conditions for this reaction. In particular, the highly useful fluorescent carbohydrate 2-NBD-glucosamine (2-NBDG, 3) can now be prepared in 75% yield with NBD-F as compared to 12% with NBD-Cl.
