174847-49-5Relevant academic research and scientific papers
Practical synthesis of (3S,4S)-3-methoxy-4-methylaminopyrrolidine
Tsuzuki, Yasunori,Chiba, Katsumi,Mizuno, Kazuhiro,Tomita, Kyoji,Suzuki, Kenji
, p. 2989 - 2997 (2001)
Three synthetic methods for the preparation of (3S,4S)-3-methoxy-4-methylaminopyrrolidine, an important intermediate in the synthesis of the novel quinolone antitumur agent, AG-7352, have been developed. By one route, an efficient and large-scale preparation of the chiral pyrrolidine could be achieved through resolution of (±)-1-Boc-3-benzylamino-4-hydroxypyrrolidine, which is prepared from either 3-pyrroline or 1,4-dichloro-2-butene.
Synthesis and structure-activity relationships of novel 7-substituted 1,4-dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acids as antitumor agents. Part 1
Tomita, Kyoji,Tsuzuki, Yasunori,Shibamori, Koh-ichiro,Tashima, Masanori,Kajikawa, Fumie,Sato, Yuji,Kashimoto, Shigeki,Chiba, Katsumi,Hino, Katsuhiko
, p. 5564 - 5575 (2007/10/03)
In an attempt to search for clinically useful antitumor agents, we have discovered that a series of 1,7-disubstituted-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids possessed moderate cytotoxic activity. We investigated the structure-acti
Compounds, processes for the preparation thereof and anti-tumor agents
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, (2008/06/13)
This invention relates to pyridone-carboxylic acid derivatives of the following formula or salts thereof: STR1 wherein R1 is a hydrogen atom, a halogen atom, etc., R2 is a carboxyl group etc., R3 is a hydrogen atom etc., A
