174847-50-8

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 174847-49-5 (+)-(3S,4S)-3-amino-1-benzyl-4-methoxypyrrolidine 
• 75-65-0 tert-butyl alcohol 
• 100-44-7 benzyl chloride 
• 128757-97-1 (+/-)-trans-3-amino-1-benzyl-4-methoxypyrrolidine 
• 429673-78-9 (+/-)-trans-3-azido-1-tert-butoxycarbonyl-4-methoxypyrrolidine 

Downstream Products

• 174847-51-9 (3S,4S)-1-benzyl-3-(N-tert-butoxycarbonyl)methylamino-4-methoxypyrrolidine 

Relevant academic research and scientific papers

Practical synthesis of (3S,4S)-3-methoxy-4-methylaminopyrrolidine

Three synthetic methods for the preparation of (3S,4S)-3-methoxy-4-methylaminopyrrolidine, an important intermediate in the synthesis of the novel quinolone antitumur agent, AG-7352, have been developed. By one route, an efficient and large-scale preparation of the chiral pyrrolidine could be achieved through resolution of (±)-1-Boc-3-benzylamino-4-hydroxypyrrolidine, which is prepared from either 3-pyrroline or 1,4-dichloro-2-butene.

Compounds, processes for the preparation thereof and anti-tumor agents

This invention relates to pyridone-carboxylic acid derivatives of the following formula or salts thereof: STR1 wherein R1 is a hydrogen atom, a halogen atom, etc., R2 is a carboxyl group etc., R3 is a hydrogen atom etc., A

7-(1-PYRROLIDINYL)-3-QUINOLONE-AND-NAPHTHYRIDONECARBOXYLIC ACID DERIVATIVES AS ANTIBACTERIAL AGENTS AND FEED ADDITIVES

7-(1-Pyrrolidinyl)-3-quinolone- and -naphthyridonecarboxylic acid derivatives as antibacterial agents and feed additives, of the formula in which X1 is halogen, X2 is hydrogen, halogen, amino or other radical, R1 is alkyl, cycloalkyl, optionally substituted phenyl or other radical, R2 is hydrogen, alkyl or a dioxolylmethyl radical, R 3 i s A is N, CH, C-halogen, or the like, or forms a bridge with R1, and addition products thereof