111373-03-6Relevant articles and documents
Rapid and efficient synthesis of 1-Arylpiperazines under microwave irradiation
Jaisinghani, Harsha G.,Khadilkar, Bhushan M.
, p. 6875 - 6876 (1997)
1-Arylpiperazines, finding wide applicability in pharmaceuticals were synthesized easily under microwave irradiation from bis(2-chloroethyl)amine hydrochloride and substituted anilines without any solvent. The reaction time was just 1-3 mins. 1-Arylpiperazines were synthesized in 53 to 73% yields. Potent serotonin ligands like Trifluoromethylphenylpiperazine (TFMPP) and 3-Chlorophenylpiperazine (mCPP) were also prepared in just 1 min and 2 mins respectively.
Pd-Catalyzed Synthesis of Piperazine Scaffolds under Aerobic and Solvent-Free Conditions
Reilly, Sean W.,Mach, Robert H.
supporting information, p. 5272 - 5275 (2016/10/31)
A facile Pd-catalyzed methodology providing an efficient synthetic route to biologically relevant arylpiperazines under aerobic conditions is reported. Electron donating and sterically hindered aryl chlorides were aminated to afford yields up to 97%, with examples using piperazine as solvent, illustrating an ecofriendly, cost-effective synthesis of these privileged structures.
Ligand-free Cu-catalyzed cyanation of aryl halides with K 4[Fe(Cn)6] in water
Ren, Yunlai,Zhao, Shuang,Tian, Xinzhe,Liu, Zhifei,Wang, Jianji,Yin, Weiping
scheme or table, p. 564 - 567 (2010/04/23)
A simple methodology for Cu-catalyzed cyanation of aryl halides with K 4[Fe(CN)6] was developed with water as the solvent in conjunction with ligand-free Cu(OAc)2·H2O as the catalyst. The suggested methodology i
