174872-57-2Relevant academic research and scientific papers
Zinc-catalyzed amide cleavage and esterification of β- hydroxyethylamides
Kita, Yusuke,Nishii, Yuji,Higuchi, Takafumi,Mashima, Kazushi
, p. 5723 - 5726 (2012/08/07)
Snipping tool: Zn(OTf)2 is an efficient catalyst for selective cleavage of amides bearing a β-hydroxyethyl group on the nitrogen atom. The mechanism involves an N,O-acyl rearrangement and transesterification. This new catalytic system can be applied to sequence-specific peptide bond scission at the amine side of a serine residue. Tf=trifluoromethanesulfonyl. Copyright
Transesterification of α-amino esters catalyzed by a tetranuclear zinc cluster: Zn4(OCOCF3)6O
Maegawa, Yusuke,Agura, Kazushi,Hayashi, Yukiko,Ohshima, Takashi,Mashima, Kazushi
supporting information; experimental part, p. 137 - 141 (2012/02/03)
Transesterification of amino acid ester derivatives was developed using a tetranuclear zinc cluster, Zn4(OCOCF3)6O, as the catalyst. Because the reaction conditions were very mild, a variety of N-protective groups and functional groups on side chains were tolerated. Georg Thieme Verlag Stuttgart. New York.
