174909-46-7Relevant academic research and scientific papers
Synthesis of water-soluble prodrugs of the cytotoxic agent Combretastatin A4
Bedford, Simon B.,Quarterman, Charmaine P.,Rathbone, Daniel L.,Slack, John A.,Griffin, Roger J.,Stevens, Malcolm F. G.
, p. 157 - 160 (1996)
Water-soluble phosphate and glycine carbamate prodrugs of the cytotoxic agent Combretastatin A4 (1) have been prepared. The phosphate prodrug was degraded slowly in plasma at 37°C. The degradation was accelerated by the addition of alkaline phosphatase.
