Bioorganic and Medicinal Chemistry Letters p. 157 - 160 (1996)
Update date:2022-08-02
Topics:
Bedford, Simon B.
Quarterman, Charmaine P.
Rathbone, Daniel L.
Slack, John A.
Griffin, Roger J.
Stevens, Malcolm F. G.
Water-soluble phosphate and glycine carbamate prodrugs of the cytotoxic agent Combretastatin A4 (1) have been prepared. The phosphate prodrug was degraded slowly in plasma at 37°C. The degradation was accelerated by the addition of alkaline phosphatase.
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