174960-81-7

Basic information

• Product Name: (S)-(2-oxo-3-phenylmethanesulfonyl-piperidiny-1-yl)acetic acid
• Synonyms: (S)-(2-oxo-3-phenylmethanesulfonyl-piperidiny-1-yl)acetic acid
• CAS NO: 174960-81-7
• Molecular Weight: 326.373
• Mol File: 174960-81-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-(2-oxo-3-phenylmethanesulfonyl-piperidiny-1-yl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(2-oxo-3-phenylmethanesulfonyl-piperidiny-1-yl)acetic acid(174960-81-7)
• EPA Substance Registry System: (S)-(2-oxo-3-phenylmethanesulfonyl-piperidiny-1-yl)acetic acid(174960-81-7)

Safety Data

• Hazardous Substances Data: 174960-81-7(Hazardous Substances Data)

Upstream product

• 174960-80-6 ((S)-2-Oxo-3-phenylmethanesulfonylamino-piperidin-1-yl)-acetic acid methyl ester 
• 797752-43-3 ((S)-2-Oxo-3-phenylmethanesulfonylamino-piperidin-1-yl)-acetic acid benzyl ester 
• 92235-39-7 3(S)-<(butoxycarbonyl)amino>-2-oxopiperidine 
• 21887-64-9 N₂-(tert-butoxycarbonyl)-L-ornithine 
• 175133-83-2 (3S)-benzyl 2-(3-((tert-butoxycarbonyl)amino)-2-oxopiperidin-1-yl)acetate 
• 792884-63-0 ((S)-3-Amino-2-oxo-piperidin-1-yl)-acetic acid benzyl ester 
• 74411-97-5 3(S)-[(tert-butyloxycarbonyl)amino]-2-oxo-1-piperidineacetic acid 
• 74411-96-4 N^α-(tert-butoxycarbonyl)-N^δ-(carboxymethyl)ornithine 
• 2480-93-5 Boc-Orn(Z)-OH 

Downstream Products

• 201355-23-9 N-((S)-1-Carbamimidoyl-2-ethoxy-piperidin-3-yl)-2-((S)-2-oxo-3-phenylmethanesulfonylamino-piperidin-1-yl)-acetamide 
• 301544-61-6 C₂₅H₃₈N₈O₁₀S 
• 186261-87-0 C₂₂H₃₃N₇O₇S 

Relevant articles and documents

Design, synthesis, and structure-activity relationships of unsubstituted piperazinone-based transition state factor Xa inhibitors

A series of novel transition state factor Xa inhibitors containing a variety of lactam ring systems as central templates was synthesized in an expedient manner and allowed for a great deal of structural variability. Among them, the piperazinone-based inhibitors were found to be not only active against factor Xa but also selective over thrombin. Optimization of the P4 moiety yielded several potent compounds with IC50 below 1 nM against factor Xa.