174961-33-2Relevant academic research and scientific papers
Rational design and synthesis of a novel, selective class of thrombin inhibitors: P1-argininal derivatives incorporating P3-P4 quaternary lactam dipeptide surrogates
Semple, J. Edward,Minami, Nathaniel K.,Tamura, Susan Y.,Brunck, Terence K.,Nutt, Ruth F.,Ripka, William C.
, p. 2421 - 2426 (2007/10/03)
SAR and molecular modeling investigations on the potent and selective thrombin inhibitor 1b (CVS 1578) and related serine protease inhibitors led to the design of series 2a-g, featuring quaternary α-amino-α-benzyl-lactam scaffolds that serve as novel P3-P4 dipeptide mimics. The design, synthesis, and biological activity of these targets an presented.
3-amino-2-oxo-1-piperidineacetic derivatives as enzyme inhibitors
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, (2008/06/13)
The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease
