174971-48-3Relevant academic research and scientific papers
Total synthesis of (+)-curacin A, a marine cytotoxic agent
Hoemann, Michael Z.,Agrios, Konstantinos A.,Aube, Jeffrey
, p. 11087 - 11098 (1997)
The total synthesis of curacin A, a cytotoxic agent that interacts with the colchicine binding site on tubulin, is described. The convergent synthesis utilizes natural product and chiral pool starting materials (geraniol, serine) and asymmetric synthesis
Total synthesis of curacin A
Hoemann, Michael Z.,Agrios, Konstantinos A.,Aube, Jeffrey
, p. 953 - 956 (2007/10/03)
Curacin A (1) was synthesized in a convergent manner. The key steps were (1) a Julia coupling to establish the stereochemistry of the C(7-10) diene, (2) a Wittig reaction to establish the stereochemistry of the C(3-4) alkene, and (3) a dehydrative cyclization to form the thiazoline ring system.
