Total synthesis of (+)-curacin A, a marine cytotoxic agent

Article abstract of DOI:10.1016/S0040-4020(97)00368-2

The total synthesis of curacin A, a cytotoxic agent that interacts with the colchicine binding site on tubulin, is described. The convergent synthesis utilizes natural product and chiral pool starting materials (geraniol, serine) and asymmetric synthesis