1750-12-5

Basic information

• Product Name: 4-Amino-3-hydrazino-1,2,4-triazol-5-thiol
• Synonyms: AKOS B029009;4-AMINO-5-HYDRAZINO-4H-1,2,4-TRIAZOLE-3-THIOL;4-Amino-3-hydrazino-1,2,4-triazol-5-thiol;4-AMINO-3-HYDRAZINO-5-MERCAPTO-1,2,4-TRIAZOLE;PURPAID(R);PURPALD;PURPALD(R);2,4-triazolidin-3-one,4-amino-5-thioxo-hydrazone
• CAS NO: 1750-12-5
• Molecular Formula: C₂H₆N₆S
• Molecular Weight: 146.17424
• EINECS: 217-135-8
• Product Categories: Aldehyde Labeling Reagents;Heterocycles;Sulfur & Selenium Compounds
• Mol File: 1750-12-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 228-230 °C (dec.)(lit.)
• Boiling Point: 275 °C at 760 mmHg
• Flash Point: 120.1 °C
• Appearance: Beige solid
• Density: 2.31 g/cm³
• Storage Temp.: 0-6°C
• Solubility: Soluble in Dimethyl sulfoxide. (DMSO)
• PKA: 8.52±0.20(Predicted)
• BRN: 134867
• CAS DataBase Reference: 4-Amino-3-hydrazino-1,2,4-triazol-5-thiol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-3-hydrazino-1,2,4-triazol-5-thiol(1750-12-5)
• EPA Substance Registry System: 4-Amino-3-hydrazino-1,2,4-triazol-5-thiol(1750-12-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: 1325
• WGK Germany: 3
• TSCA: Yes
• HazardClass: 4.1
• PackingGroup: III
• Hazardous Substances Data: 1750-12-5(Hazardous Substances Data)

Usage

Chemical Properties

Beige solid

Uses

Different sources of media describe the Uses of 1750-12-5 differently. You can refer to the following data:
1. A reagent for the determination of aldehydes and other reactive chemicals
2. 4-Amino-3-hydrazino-5-mercapto-1,2,4-triazole is a reagent used in the determination of aldehydes and other reactive chemicals.was used in purpald assay for determination of bacterial polysaccharides containing substituted or unsubstituted glycol in residues such as glycerol, ribitol, arabinitol, furanosyl galactose and sialic acid. It was used as chromogen during the determination of catalase activity in small tissue samples. It was used as reagent in determination of formaldehyde. It was used for derivatization of neutral monosaccharides during HPLC.
3. Purpald? was used in purpald assay for determination of bacterial polysaccharides containing substituted or unsubstituted glycol in residues such as glycerol, ribitol, arabinitol, furanosyl galactose and sialic acid. It was used as chromogen during the determination of catalase activity in small tissue samples. It was used as reagent in determination of formaldehyde. It was used for derivatization of neutral monosaccharides during HPLC.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 26, p. 355, 1989 DOI: 10.1002/jhet.5570260216

Purification Methods

Recrystallise Purpald from H2O (0.6g in 300-400mL). The benzylidene derivative has m 245-246o(dec) from i-PrOH [Hoggarth J Chem Soc 4817 1952, Dickinson & Jacobson J Chem Soc, Perkin Trans I 975 1975.[Beilstein 26 III/IV 547.]

InChI:InChI=1/C2H7N6S/c3-5-1-6-7-2(9)8(1)4/h3-4H2,(H3,5,6,7,9)

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Relevant articles and documents

Synthesis of 3-Pyrazolyl-1,2,4-Triazoles via One-Pot Multicomponent Reaction in Phosphoric Acid

A high-yielding synthetic route towards pyrazolyl-[1,2,4]triazole derivatives has been developed via one-pot multicomponent reaction of polyfunctionalized triazoles, DMF-DMA, acetophenone, ethyl cyanoacetate, and/or 3-oxo-3-phenylpropanenitrile in ortho-phosphoric acid (85%). In the same manner, a new series of 2-triazolyl-tetrahydro-indazol-4-ones and pyrazolo[3,4-d]pyrimidines has been synthesized by reaction of triazoles, DMF-DMA and 1,3-cyclohexanediones and/or barbituric acid, respectively. The same products were prepared a classical manner via reaction of triazoles with the corresponding enaminones in ortho-phosphoric acid (85%).

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One-pot, Multicomponent Cascade Reaction for the Synthesis of Various Aralkyl/alkylthio-3,5-dimethyl-1H-pyrazolyl-4H-1,2,4-triazol-4-amine and Their Docking Studies

A facile and simple one-pot procedure for the synthesis of various aralkyl/alkylthio-3,5-dimethyl-1H-pyrazolyl-4H-1,2,4-triazol-4-amines has been described via a multicomponent reaction of 4-amino-5-hydrazinyl-4H-1,2,4-triazole-3-thiol, acetylacetone, and various aryl/alkyl halides in good yields. All the newly synthesized compounds were characterized by using analytical and spectral studies. Our in silico studies confirmed that 4e, 4f, 4g, and 4j have the best inhibition activity among the synthesized compounds with a high selective index against the Tubulin protein and showed best interactions with receptor structure. The present study provides a novel series of compounds with a promising inhibitor to prevent on Tubulin protein.

Synthesis and Characterisation of Copper(II) Complexes of 4-Amino-3-hydrazino-5-mercapto-1,2,4-triazole

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