1751-78-6 Usage
General Description
1-Oxo-2,3,4,9-tetrahydro-1H-β-carboline-6-carboxylic acid is a chemical compound that belongs to the class of β-carbolines, which are heterocyclic compounds derived from tryptophan. This particular compound has a carboxylic acid functional group and a ketone group, as indicated by the "1-oxo" prefix. β-carbolines have been found to have a wide range of biological activities, including neuroprotective, antioxidant, and cytotoxic effects. Studies have also shown that some β-carbolines may have potential anticancer and antiviral properties. Additionally, β-carbolines have been investigated for their potential use in the treatment of neurodegenerative diseases and psychiatric disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 1751-78-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,7,5 and 1 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1751-78:
(6*1)+(5*7)+(4*5)+(3*1)+(2*7)+(1*8)=86
86 % 10 = 6
So 1751-78-6 is a valid CAS Registry Number.
1751-78-6Relevant articles and documents
From pyrroles to 1-oxo-2,3,4,9-tetrahydro-1H-β-carbolines: A new class of orally bioavailable mGluR1 antagonists
Fabio, Romano Di,Micheli, Fabrizio,Alvaro, Giuseppe,Cavanni, Paolo,Donati, Daniele,Gagliardi, Tatiana,Fontana, Gabriele,Giovannini, Riccardo,Maffeis, Micaela,Mingardi, Anna,Tranquillini, Maria Elvira,Vitulli, Giovanni
, p. 2254 - 2259 (2008/02/03)
Exploiting the SAR of the known pyrrole derivatives, a new class of mGluR1 antagonists was designed by replacement of the pyrrole core with an indole scaffold and consequent cyclization of the C-2 position into a tricyclic β-carboline template. The appropriate exploration of the position C-6 with a combination of H-bond acceptor groups coupled with bulky/lipophilic moieties led to the discovery of a new series of mGluR1 antagonists. These compounds exhibited a non-competitive behavior, excellent pharmacokinetic properties, and good in vivo activity in animal models of acute and chronic pain, after oral administration.
