175135-22-5

Usage

Uses

Used in Pharmaceutical Industry:
2-(N-PROPYLTHIO)NICOTINIC ACID is used as a reagent for the synthesis of product inhibitors of glucose transporters 1 and 3. These inhibitors play a crucial role in regulating glucose uptake in cells, which can be beneficial for the development of treatments targeting conditions such as diabetes and obesity. By modulating glucose transporter activity, 2-(N-PROPYLTHIO)NICOTINIC ACID can contribute to the advancement of therapeutic strategies for these metabolic disorders.

InChI:InChI=1/C9H11NO2S/c1-2-6-13-8-7(9(11)12)4-3-5-10-8/h3-5H,2,6H2,1H3,(H,11,12)/p-1

Upstream product

• 38521-46-9 3-carboxy-2-mercaptopyridine 
• 107-08-4 1-iodo-propane 

Downstream Products

• 1383624-85-8 N-(4,4-difluorocyclohexyl)-2-propylsulfanylpyridine-3-carboxamide 
• 175135-24-7 C₉H₁₀ClNOS 
• 1383624-83-6 N-cyclohexyl-N-methyl-2-propylsulfanylpyridine-3-carboxamide 
• 141841-69-2 N-cyclohexyl-2-propylsulfanylpyridine-3-carboxamide 

Relevant academic research and scientific papers

Novel compounds comprising thionicotinamide scaffold, its enantiomers, its diastereomers or its pharmaceutically acceptable salt and antiviral composition containing the same as an active ingredient

The present invention relates to a novel compound including a thionicotinamide scaffold, an enantiomer thereof, a diastereomer or a pharmaceutically acceptable salt, and antiviral composition containing the same as an active ingredient. According to the present invention, the novel compound which is represented by chemical formula 1 exhibits remarkably excellent antiviral activities against influenza virus, and barely causes side effects due to low cytotoxicity. Thus, the pharmaceutical composition containing the same as the active ingredient can be useful for preventing or treating diseases caused by influenza virus infection.COPYRIGHT KIPO 2018

THIOARYL DERIVATIVES AS GPR120 AGONISTS

The present invention relates to thioaryl derivatives of Formula 1 as defined in the specification, a method for preparing the same, a pharmaceutical composition comprising the same and use thereof. The thioaryl derivatives of Formula 1 according to the present invention promote GLP-1 formation in the gastrointestinal tract and improve insulin resistance in macrophages, pancreas cells, etc. due to anti-inflammatory action, and can accordingly be effectively used for preventing or treating diabetes, complications of diabetes, inflammation, obesity, non-alcoholic fatty liver, steatohepatitis or osteoporosis.