175135-24-7 Usage
General Description
2-(Propylthio)pyridine-3-carbonyl chloride is a specific chemical compound that is used in organic synthesis and pharmaceutical research. It is known for its strong and reactive nature as a carbonyl chloride, making it a useful reagent in the creation of various organic compounds. 2-(PROPYLTHIO)PYRIDINE-3-CARBONYL CHLORIDE is a derivative of pyridine and contains a propylthio group, which provides specificity in its reactivity and potential applications. 2-(Propylthio)pyridine-3-carbonyl chloride is commonly used in the development of pharmaceutical drugs and other organic compounds due to its versatile and reactive properties.
Check Digit Verification of cas no
The CAS Registry Mumber 175135-24-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,5,1,3 and 5 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 175135-24:
(8*1)+(7*7)+(6*5)+(5*1)+(4*3)+(3*5)+(2*2)+(1*4)=127
127 % 10 = 7
So 175135-24-7 is a valid CAS Registry Number.
InChI:InChI=1/C9H10ClNOS/c1-2-6-13-9-7(8(10)12)4-3-5-11-9/h3-5H,2,6H2,1H3
175135-24-7Relevant articles and documents
Discovery of a potent, selective, and orally bioavailable acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor: Discovery of 2-[(3 s)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]- 3-piperidyl]acetic acid (AZD4017)
Scott, James S.,Bowker, Suzanne S.,Deschoolmeester, Joanne,Gerhardt, Stefan,Hargreaves, David,Kilgour, Elaine,Lloyd, Adele,Mayers, Rachel M.,McCoull, William,Newcombe, Nicholas J.,Ogg, Derek,Packer, Martin J.,Rees, Amanda,Revill, John,Schofield, Paul,Selmi, Nidhal,Swales, John G.,Whittamore, Paul R. O.
experimental part, p. 5951 - 5964 (2012/08/07)
Inhibition of 11β-HSD1 is an attractive mechanism for the treatment of obesity and other elements of the metabolic syndrome. We report here the discovery of a nicotinic amide derived carboxylic acid class of inhibitors that has good potency, selectivity, and pharmacokinetic characteristics. Compound 11i (AZD4017) is an effective inhibitor of 11β-HSD1 in human adipocytes and exhibits good druglike properties and as a consequence was selected for clinical development.
