175136-60-4

Usage

Uses

Used in Organic Synthesis:
1-[3,5-bis(trifluoromethyl)phenyl]pyrrole serves as a versatile building block in organic synthesis, facilitating the creation of a wide range of complex organic molecules. Its unique structure and reactivity make it a valuable component in the synthesis of novel compounds with tailored properties.
Used in Pharmaceutical Research:
In pharmaceutical research, 1-[3,5-bis(trifluoromethyl)phenyl]pyrrole is utilized as a key intermediate for the development of new drugs. Its distinctive chemical features allow for the design of molecules with improved pharmacological profiles, such as enhanced potency, selectivity, and reduced side effects.
Used in Material Science:
1-[3,5-bis(trifluoromethyl)phenyl]pyrrole also finds applications in material science, where its unique properties can be harnessed to develop new materials with specific characteristics. These materials may have potential uses in various industries, such as electronics, coatings, and advanced materials for specialized applications.
Used in Drug Discovery:
Due to its enhanced bioavailability and metabolic stability, 1-[3,5-bis(trifluoromethyl)phenyl]pyrrole is a promising candidate for drug discovery. It can be employed as a starting point or a modifying group in the design of new pharmaceuticals, potentially leading to the development of more effective and safer drugs for various therapeutic areas.

InChI:InChI=1/C12H7F6N/c13-11(14,15)8-5-9(12(16,17)18)7-10(6-8)19-3-1-2-4-19/h1-7H

Upstream product

• 109-97-7 pyrrole 
• 328-70-1 3,6-bis(trifluoromethyl)bromobenzene 
• 328-73-4 3,5-bis(trifluoromethyl)iodobenzene 

Relevant academic research and scientific papers

Electronically Strongly Coupled Divinylheterocyclic-Bridged Diruthenium Complexes

Complexes [{Ru(CO)Cl(PiPr3)2}2(μ-2,5-(CH=CH)2-cC4H2E] (E=NR; R=C6H4-4-NMe2 (10a), C6H4-4-OMe (10b), C6H4-4-Me (10c), C6H5 (10d), C6H4-4-CO2Et (10e), C6H4-4-NO2 (10f), C6H3-3,5-(CF3)2 (10g), CH3 (11); E=O (12), S (13)) are discussed. The solid state structures of four alkynes and two complexes are reported. (Spectro)electrochemical studies show a moderate influence of the nature of the heteroatom and the electron-donating or -withdrawing substituents R in 10a-g on the electrochemical and spectroscopic properties. The CVs display two consecutive one-electron redox events with ΔE°′=350-495 mV. A linear relationship between ΔE°′ and the σp Hammett constant for 10a-f was found. IR, UV/Vis/NIR and EPR studies for 10+-13+ confirm full charge delocalization over the {Ru}CH=CH-heterocycle-CH=CH{Ru} backbone, classifying them as Class III systems according to the Robin and Day classification. DFT-optimized structures of the neutral complexes agree well with the experimental ones and provide insight into the structural consequences of stepwise oxidations.

Improved Buchwald-Hartwig Amination by the Use of Lipids and Lipid Impurities

The development of green Buchwald-Hartwig aminations has long been considered challenging, due to the high sensitivity of the reaction to the environment. Here we show that food-grade and waste vegetable oils, triglycerides originating from animals, and natural waxes can serve as excellent green solvents for Buchwald-Hartwig amination. We further demonstrate that amphiphiles and trace ingredients present in triglycerides as additives have a decisive effect on the yields of Buchwald-Hartwig aminations.