175136-82-0

Usage

Uses

Used in Pharmaceutical Industry:
2-CHLORO-6-FLUOROBENZYLIDENEACETONE is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to impart antimicrobial and antifungal properties to the final drug products. Its potent activity against a range of pathogens makes it a promising candidate for the development of new treatments for infectious diseases.
Used in Agricultural Applications:
2-CHLORO-6-FLUOROBENZYLIDENEACETONE is used as a potential pesticide in agriculture due to its demonstrated effectiveness against various pests and fungi. Its use in this industry can help improve crop yields and protect plants from diseases, contributing to more sustainable and efficient agricultural practices.
Used in Biotechnology:
2-CHLORO-6-FLUOROBENZYLIDENEACETONE is used in biotechnology for its potential applications in the development of new drugs and therapies. Its antimicrobial and antifungal properties can be harnessed to create innovative solutions for treating various diseases and improving human health.

InChI:InChI=1/C10H8ClFO/c1-7(13)5-6-8-9(11)3-2-4-10(8)12/h2-6H,1H3/b6-5+

Upstream product

• 387-45-1 2-chloro-6-fluorobenzaldehyde 
• 67-64-1 acetone 

Downstream Products

• 1597410-57-5 (E)-S-methyl 4-(2-chloro-6-fluorophenyl)-2-oxobut-3-enethioate 

Relevant academic research and scientific papers

Dehydrozingerone Inspired Discovery of Potential Broad-Spectrum Fungicidal Agents as Ergosterol Biosynthesis Inhibitors

A series of dehydrozingerone derivatives were synthesized, and their fungicidal activities and action mechanism against Colletotrichum musae were evaluated. The bioassay result showed that most compounds exhibited excellent fungicidal activity in vitro at 50 μg mL-1. Compounds 13, 16, 18, 19, and 27 exhibited broad-spectrum fungicidal activity; especially, compounds 19 and 27 were found to have more potent fungicidal activity than azoxystrobin. The EC50 values of compounds 19 and 27 against Rhizoctonia solani were 0.943 and 0.161 μg mL-1 respectively. Moreover, compound 27 exhibited significant in vitro bactericidal activity against Xanthomonas oryzae pv. oryzae, with an EC50 value of 11.386 μg mL-1, and its curative effect (49.64%) and protection effect (51.74%) on rice bacterial blight disease was equivalent to that of zhongshengmycin (42.90%, 40.80% respectively). Compound 27 could also effectively control gray mold (87.10%, 200 μg mL-1) and rice sheath blight (100%, 200 μg mL-1 82.89%, 100 μg mL-1) in vivo. Preliminary action mechanism study showed that compound 27 mainly acted on the cell membrane and significantly inhibited ergosterol biosynthesis in Colletotrichum musae.

Dehydrozingerone derivative and preparation method and application thereof

The invention provides a dehydrozingerone derivative as shown in the description. R-R are each independently selected from hydrogen or halogen or a nitro group or an alkyl group or a substitutedalkoxy group or an alkoxy group or a hydroxyl group; the substituent in the substituted alkoxy group is selected from one or multiple of halogen, a nitro group and a hydroxyl group; R and R areeach independently selected from hydrogen or halogen or nitrogen-containing heterocycle; R is selected from an alkyl group or an alkoxy group or a substituted alkoxy group; the substituent in thesubstituted alkyl group is selected from one or multiple of halogen, a nitro group and a hydroxyl group; X is selected from a hetero atom or a hydroxylamine group. The dehydrozingerone derivative hasbroad-spectrum activity against plant pathogenic fungi and bacteria, and has certain nematicidal activity, and is a lead compound with the broad biological activity.

Unsaturated oxime ethers and their use as fungicides

The present invention relates to certain oxime ether compounds, compositions containing these compounds, and methods for controlling fungi by the use of a fungitoxic amount of the compounds or compositions.