175137-14-1

Basic information

• Product Name: 1-PHENYL-5-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBONYL CHLORIDE
• Synonyms: 1-PHENYL-5-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBONYL CHLORIDE;1-PHENYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBONYL CHLORIDE;1-Phenyl-5-(trifluoromethyl)pyrazole-4-carbonyl chloride 97%;1-Phenyl-5-(trifluoromethyl)pyrazole-4-carbonylchloride97%;1-Phenyl-5-(trifluoromethyl)pyrazole-4-carbonyl;1-Phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carbonyl chloride 97%;1-Phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carbonylchloride97%;TIMTEC-BB SBB001093
• CAS NO: 175137-14-1
• Molecular Formula: C₁₁H₆ClF₃N₂O
• Molecular Weight: 274.63
• Mol File: 175137-14-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 40 °C
• Boiling Point: 110 °C
• Flash Point: 175.3°C
• Appearance: /
• Density: 1.55g/cm³
• Vapor Pressure: 8.13E-05mmHg at 25°C
• Refractive Index: 1.556
• CAS DataBase Reference: 1-PHENYL-5-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PHENYL-5-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBONYL CHLORIDE(175137-14-1)
• EPA Substance Registry System: 1-PHENYL-5-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBONYL CHLORIDE(175137-14-1)

Safety Data

• Hazard Codes: Xi,C
• Statements: 34
• Safety Statements: 26-36/37/39
• RIDADR: 3265
• HazardClass: CORROSIVE
• Hazardous Substances Data: 175137-14-1(Hazardous Substances Data)

Usage

General Description

1-Phenyl-5-(trifluoromethyl)pyrazole-4-carbonyl chloride is a specific chemical compound that falls under the broad classification of organofluorines. These are organic compounds that have been substituted with a trifluoromethyl group. This chemical compound has a pyrazole ring, which consists of four carbon atoms and two nitrogen atoms in an unsaturated five-member loop. The ring is also substituted with a phenyl group and a carbonyl chloride group. Due to its chemical structure, it can participate in various chemical reactions and might be used as an intermediate in pharmaceuticals, agrochemicals, and dye industries. Its properties and potential hazards are usually investigated through specific material safety data sheets.

InChI:InChI=1/C11H6ClF3N2O/c12-10(18)8-6-16-17(9(8)11(13,14)15)7-4-2-1-3-5-7/h1-6H

Upstream product

• 100-63-0 phenylhydrazine 
• 112055-34-2 ethyl 1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate 
• 571-55-1 ethyl 2-(ethoxymethylidene)-4,4,4-trifluoro-3-oxobutanoate 
• 98534-81-7 1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid 

Downstream Products

• 1265322-68-6 (S)-1-((S)-2-hydroxy-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidine-3-carboxylic acid 
• 1125886-02-3 C₁₆H₁₁F₃N₄O 
• 848853-21-4 methyl ({4'-[({[1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl]carbonyl}amino)methyl][1,1'-biphenyl]-4-yl}oxy)acetate 

Relevant articles and documents

Synthesis, Biological Evaluation, and 3D-QSAR Studies of N-(Substituted pyridine-4-yl)-1-(substituted phenyl)-5-trifluoromethyl-1 H-pyrazole-4-carboxamide Derivatives as Potential Succinate Dehydrogenase Inhibitors

A series of new fungicides that can inhibit the succinate dehydrogenase (SDH) was classified and named as SDH inhibitors by the Fungicide Resistance Action Committee in 2009. To develop more potential SDH inhibitors, we designed and synthesized a novel se

SPHINGOSINE-1-PHOSPHATE RECEPTOR AGONISTS

Disclosed are compounds of Formula (I), or a stereoisomer or a pharmaceutically acceptable salt thereof, wherein: A is formula (II) Q is a substituted 5-membered monocyclic heteroaryl group; W is CH2, O, or NH; and R1, R2, R3, R4, R5, R6, m, n, t, and x are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.