175140-34-8Relevant academic research and scientific papers
C-O bond formation in a microfluidic reactor: High yield SNAr substitution of heteroaryl chlorides
Alam, Mohammad Parvez,Jagodzinska, Barbara,Campagna, Jesus,Spilman, Patricia,John, Varghese
, p. 2059 - 2062 (2016)
This study describes our development of a novel and efficient procedure for C-O bond formation under mild conditions, for coupling heteroaryl chlorides with phenols or primary aliphatic alcohols. We utilized a continuous-flow microfluidic reactor for C-O bond formation in electron-deficient pyrimidines and pyridines in a much more facile manner with a cleaner reaction profile, high yield, quick scalability, and without the need for the transition metal catalyst. This approach can be of general utility to make C-O bond containing intermediates of industrial importance in a continuous and safe manner.
Corticotropin releasing factor antagonists
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, (2008/06/13)
Corticotropin-releasing factor (CRF) antagonists having the formulae wherein the dashed lines, A, B, Y, Z, G, R3, R4, R5, R6, R16 and R17 are as defined in the application, and processes fo
