175140-35-9

Basic information

• Product Name: Pyridine, 4-chloro-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-
• CAS NO: 175140-35-9
• Molecular Formula: C16H18ClNO
• Molecular Weight: 275.778
• Mol File: 175140-35-9.mol

Chemical Properties

• CAS DataBase Reference: Pyridine, 4-chloro-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 4-chloro-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-(175140-35-9)
• EPA Substance Registry System: Pyridine, 4-chloro-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-(175140-35-9)

Safety Data

• Hazardous Substances Data: 175140-35-9(Hazardous Substances Data)

Upstream product

• 4664-13-5 2,4-dihydroxy-3,6-dimethylpyridine 
• 83791-90-6 2,4-dichloro-3,6-dimethylpyridine 
• 527-60-6 Mesitol 

Downstream Products

• 175139-82-9 [3,6-dimethyl-2-(2,4,6-trimethyl-phenoxy)-pyridin-4-yl]-ethyl-amine 
• 175139-41-0 4-(1-Ethyl-propoxy)-3,6-dimethyl-2-(2,4,6-trimethyl-phenoxy)-pyridine 
• 1013652-46-4 cis/trans-4-(1-ethyl-propenyloxy)-3,6-dimethyl-2-(2,4,6-trimethyl-phenoxy)-pyridine 
• 175139-63-6 3,6-Dimethyl-4-(tetrahydro-furan-3-yloxy)-2-(2,4,6-trimethyl-phenoxy)-pyridine 

Relevant articles and documents

Regioselective addition of mesitol to a 2,4-dichloropyridine

The regioseleethity of the addition of 2,4,6-trimethylphenol to 2,4-dichloro-3,6-dimethylpyridine can be controlled by the proper choice of catalyst and solvent. The use of catalytic eopper(I) salts and pyridine as solvent results in exclusive addition at

Synthesis and SAR of 2-aryloxy-4-alkoxy-pyridines as potent orally active corticotropin-releasing factor 1 receptor antagonists

A series of 2-aryloxy-4-alkoxy-pyridines (1) was identified as novel, selective, and orally active antagonists of the corticotropin-releasing factor 1 (CRF1) receptor. Among these, compound 2 (CP-316311) is a potent and selective CRF1/sub

Process for converting 2,4-dichloropyridines into 2-aryloxy-4-chloropyridines

This invention relates to a process for converting 2,4-dichloropyridines into 2-aryloxy-4-chloropyridines, comprising reacting a compound of formula (I), wherein R1is (C1-C4)alkyl; R2is methyl or ethyl; and R3, R4and R5are selected, independently, from (C1-C4)alkyl and (C1-C4)alkoxy; or a pharmaceutically acceptable salt thereof; comprising reacting a compound of formula (II), wherein R1and R2are defined as above, with a compound of formula (III), wherein R3, R4and R5are defined as above, in the presence of a base that is capable of deprotonating the compound of formula (III), optionally in the presence of an organometallic halide or oxide and a suitable solvent, and then optionally converting the resulting compound of formula (I) into a pharmaceutically acceptable salt of such compound.

Method of treating heart failure

This invention relates to method for treating a mammal which presents with heart failure comprising administering to a mammal a therapeutically effective amount of wherein 4-(1-ethyl-propoxy)-3,6-dimethyl-2-(2,4,6-trimethyl-phenoxy)-pyridine and (3,6-dime