175143-76-7Relevant academic research and scientific papers
Cyplecksins are covalent inhibitors of the pleckstrin homology domain of cytohesin
Hussein, Mohamed,Bettio, Martina,Schmitz, Anton,Hannam, Jeffrey S.,Theis, Julian,Mayer, Günter,Dosa, Stefan,Gütschow, Michael,Famulok, Michael
supporting information, p. 9529 - 9533 (2013/09/23)
The covalent grip: A new class of 5-bromobarbiturates (Cyplecksins; see structure) act by a covalent mechanism to inhibit the biological function of the pleckstrin homology domain of cytohesins, small guanine nucleotide exchange factors for the Ras-like ARF-GTPases. In cells, Cyplecksins interfere with the phosphoinositol-dependent membrane recruitment of cytohesins. Cyplecksins may be useful in validating cytohesins as potential drug targets. Copyright
Conjugate addition reactions of some methylidene 1-benzylpyrimidinetrione derivatives
Abdelghani, Essam
, p. 2413 - 2421 (2007/10/03)
1-Benzyl-2,4,6-pyrimidinetrione (1) reacts at C-5 with aldehydes and the isolated products can easily undergo base-induced transformations by Michael addition. On the contrary,the action of POC13 or piperidine/AcOH on the title trione afforded pyrimido[4′,5prime;:4,5]furo[2,3-d]pyrimidine (16) and a dimer (17), respectively, which in turn, undergo cyclocondensation in Ac2O.
Imidazopyridine or imidazopyrimidine compounds, their production and use
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, (2008/06/13)
This invention provides a new condensed imidazole compound possessing inhibitory activity of adhesion molecule expression. This invention also provides a therapeutic and prophylactic agent for diabetic nephritis and/or autoimmune disease and an immunosuppressor for organ transplantation.
