28311-14-0

Upstream product

• 91360-95-1 N-benzylbarbituric acid 
• 100-52-7 benzaldehyde 
• 538-32-9 benzylurea 

Downstream Products

• 420801-29-2 N'-[3-benzyl-2,6-dioxo-5-benzylidenetetrahydro-4(1H)-pyrimidinylidene]formic hydrazide 
• 1455482-92-4 1,5-dibenzyl-5-bromo-pyrimidine-2,4,6-trione 
• 175143-76-7 1,5-dibenzyl-2,4,6(1H,3H,5H)-pyrimidinetrione 

Relevant academic research and scientific papers

Cyplecksins are covalent inhibitors of the pleckstrin homology domain of cytohesin

The covalent grip: A new class of 5-bromobarbiturates (Cyplecksins; see structure) act by a covalent mechanism to inhibit the biological function of the pleckstrin homology domain of cytohesins, small guanine nucleotide exchange factors for the Ras-like ARF-GTPases. In cells, Cyplecksins interfere with the phosphoinositol-dependent membrane recruitment of cytohesins. Cyplecksins may be useful in validating cytohesins as potential drug targets. Copyright

Conjugate addition reactions of some methylidene 1-benzylpyrimidinetrione derivatives

1-Benzyl-2,4,6-pyrimidinetrione (1) reacts at C-5 with aldehydes and the isolated products can easily undergo base-induced transformations by Michael addition. On the contrary,the action of POC13 or piperidine/AcOH on the title trione afforded pyrimido[4′,5prime;:4,5]furo[2,3-d]pyrimidine (16) and a dimer (17), respectively, which in turn, undergo cyclocondensation in Ac2O.