870837-21-1

Basic information

• Product Name: METHYL 3-METHOXY-4-(4-METHYL-1-IMIDAZOLYL)BENZOATE
• Synonyms: METHYL 3-METHOXY-4-(4-METHYL-1-IMIDAZOLYL)BENZOATE;methyl 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzoate;3-METHOXY-4-(4-METHYL-IMIDAZOL-1-YL)-BENZOIC ACID METHYL ESTER;Benzoic acid, 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)-, methyl ester
• CAS NO: 870837-21-1
• Molecular Formula: C₁₃H₁₄N₂O₃
• Molecular Weight: 246.26
• Mol File: 870837-21-1.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: METHYL 3-METHOXY-4-(4-METHYL-1-IMIDAZOLYL)BENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 3-METHOXY-4-(4-METHYL-1-IMIDAZOLYL)BENZOATE(870837-21-1)
• EPA Substance Registry System: METHYL 3-METHOXY-4-(4-METHYL-1-IMIDAZOLYL)BENZOATE(870837-21-1)

Safety Data

• Hazardous Substances Data: 870837-21-1(Hazardous Substances Data)

Usage

General Description

Methyl 3-methoxy-4-(4-methyl-1-imidazolyl)benzoate is a chemical compound with the molecular formula C16H16N2O3. It is an ester of benzoic acid and is commonly used in the fragrance and flavor industries. METHYL 3-METHOXY-4-(4-METHYL-1-IMIDAZOLYL)BENZOATE has a benzene ring with a methoxy group and a methyl-imidazolyl group attached, providing unique aromatic properties. It is often utilized as a flavoring agent in food and beverages, as well as in the production of perfumes and cosmetics. Additionally, it may also have pharmaceutical applications due to its aromatic and functional properties.

Upstream product

• 619-14-7 3-hydroxy-4-nitro-benzoic acid 
• 1280150-10-8 3-fluoro-4-(4-methyl-1H-imidazol-1-yl)benzonitrile 
• 1243204-92-3 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzonitrile 
• 67-56-1 methanol 
• 243128-37-2 4-fluoro-3-methoxybenzonitrile 
• 64248-62-0 3,4-Difluorobenzonitrile 
• 5081-37-8 methyl 3-methoxy-4-nitrobenzoate 
• 700834-18-0 4-formylamino-3-methoxybenzoic acid methyl ester 
• 41608-64-4 methyl 3-methoxy-4-aminobenzoate 
• 822-36-6 4-methyl-1H-imidazole 
• 175153-75-0 3-methoxy-4-trifluoromethane-sulfonyloxy-benzoic acid methyl ester 
• 870837-20-0 4-[formyl-(2-oxopropyl)amino]-3-methoxybenzoic acid methyl ester 

Downstream Products

• 870837-18-6 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde 
• 937026-26-1 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzoic acid 
• 1242314-39-1 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzohydrazide 
• 1262106-88-6 tert-butyl 2-{[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]carbonyl}hydrazinecarboxylate 
• 1363145-33-8 ethyl 8-(3,4-difluorophenyl)-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine-8-carboxylate 
• 1363146-39-7 ethyl 3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine-8-carboxylate 
• 1363146-44-4 ethyl 8-chloro-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine-8-carboxylate 
• 870850-40-1 (E)-1-(4-(2-carboxy-5-chloropent-1-en-1-yl)-2-methoxyphenyl)-4-methyl-1H-imidazol-3-ium 2,2,2-trifluoroacetate 
• 870843-26-8 tert-butyl 5-chloro-2-{1-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-(E)-methylidene}valerate 
• 1352130-00-7 (S,E)-5-chloro-N-(2-hydroxy-1-(3,4,5-trifluorophenyl)ethyl)-2-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)pentanamide 
• 870852-75-8 (S,E)-1-(2-hydroxy-1-(3,4,5-trifluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)piperidin-2-one 
• 1352130-01-8 (S,E)-1-(2-(aminooxy)-1-(3,4,5-trifluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)piperidin-2-one 
• 870838-69-0 (E)-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]acrylic acid ethyl ester 
• 870837-69-7 4-(5-chloro-1H-imidazol-1-yl)-3-methoxybenzaldehyde 

Relevant articles and documents

Synthesis of the γ-Secretase Modulator MK-8428

The synthesis of the γ-secretase modulator MK-8428 (1) is described. The synthesis is highlighted by an enzyme-catalyzed reaction to access 3,4,5-trifluoro-(S)-phenylglycine, a 1-pot activation/displacement/deprotection sequence to introduce the aminooxy functionality and a dehydrative intramolecular cyclization under mild conditions to form the oxadiazine heterocycle of 1. In situ reaction monitoring was employed to understand the deleterious role of water during the formation of a methanesulfonate ester in the 1-pot activation/displacement/deprotection sequence.

HETEROCYCLIC COMPOUND AND USE THEREOF

The present invention provides a heterocycle derivative having a superior amyloid β production inhibitory activity and/or a superior γ-secretase modulation activity, and use thereof. A compound represented by the formula (I): wherein each symbol is as defined in the present specification, or a salt thereof.

UREA TYPE CINNAMIDE DERIVATIVE

Disclosed is a compound represented by the formula (I) below or a pharmacologically acceptable salt thereof. Also disclosed is a use of the compound or salt as a pharmaceutical product. (In the formula, Ar1 represents an imidazolyl group which may be substituted with a C1-6 alkyl group; Ar2 represents a phenyl group which may be substituted with a C1-6 alkoxy group; X1 represents a single bond; R1 and R2 respectively represent a C1-6 alkyl group or the like which may be substituted with a substituent such as a 5- to 14-membered aromatic heterocyclic group; and R3 represents a hydrogen atom or the like.)