175205-24-0

Basic information

• Product Name: 1-(2-(TRIFLUOROMETHOXY)PHENYL)-2-THIOUREA
• Synonyms: 1-(2-(TRIFLUOROMETHOXY)PHENYL)-2-THIOUREA;N-[2-(trifluoromethoxy)phenyl]thiourea;1-(2-(TrifluoroMethoxy)phenyl)thiourea
• CAS NO: 175205-24-0
• Molecular Formula: C8H7F3N2OS
• Molecular Weight: 236.21
• Mol File: 175205-24-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 148-152°C
• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-(2-(TRIFLUOROMETHOXY)PHENYL)-2-THIOUREA(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-(TRIFLUOROMETHOXY)PHENYL)-2-THIOUREA(175205-24-0)
• EPA Substance Registry System: 1-(2-(TRIFLUOROMETHOXY)PHENYL)-2-THIOUREA(175205-24-0)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 175205-24-0(Hazardous Substances Data)

Usage

General Description

1-(2-(Trifluoromethoxy)phenyl)-2-thiourea is a chemical compound with the formula C8H6F3N3OS. It is a thiourea derivative with a trifluoromethoxyphenyl group attached to the carbon atom. 1-(2-(TRIFLUOROMETHOXY)PHENYL)-2-THIOUREA is used in research and industry as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has been studied for its potential anti-cancer and anti-inflammatory properties. Additionally, it has been used as a ligand in coordination chemistry and as a reagent in organic synthesis. Its unique structure and properties make it a valuable compound for various scientific and industrial applications.

Upstream product

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Downstream Products

• 235101-36-7 SKA-35 

Relevant articles and documents

IMIDAZOTHIADIAZOLE DERIVATIVES AS PROTEASE ACTIVATED RECEPTOR 4 (PAR4) INHIBITORS FOR TREATING PLATELET AGGREGATION

The present invention provides imidazothiadiazole compounds of Formula (I) wherein A, B, D, Rx, R1, R2, R3, X1, X2 and s are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments.

Riluzole series. synthesis and in vivo 'antiglutamate' activity of 6- substituted-2-benzothiazolamines and 3-substituted-2-imino-benzothiazolines

Two series of analogues of riluzole, a blocker of excitatory amino acid mediated neurotransmission, have been synthesized: monosubstituted 2- benzothiazolamines and 3-substituted derivatives. Of all the compounds prepared in the first series, only 2-benzothiazolamines bearing alkyl, polyfluoroalkyl, or polyfluoroalkoxy substituents in the 6-position showed potent anticonvulsant activity against administration of glutamic acid in rats. The most active compounds displaying in vivo 'antiglutamate' activity were the 6-OCF3 (riluzole), 6-OCF2CF3, 6-CF3, and 6-CF2CF3 substituted derivatives with ED50 values between 2.5 and 3.2 mg/kg i.p. Among the second series of variously substituted benzothiazolines, compounds as active as riluzole or up to 3 times more potent were identified in two series: benzothiazolines bearing a β-dialkylaminoethyl moiety and compounds with an alkylthioalkyl chain and their corresponding sulfoxides and sulfones. The most potent derivatives were 2-imino-3-(2-methylthio)- and 2-imino-3-(2- methylsulfinyl)-ethyl-6-trifluoromethoxybenzothiazolines (61 and 64, ED50 = 1.0 and 1.1 mg/kg i.p., respectively). In addition, intraperitoneal administration of some of the best benzothiazolines protected mice from mortality produced by hypobaric hypoxia.