170502-06-4Relevant academic research and scientific papers
SUBSTITUTED AZOLE DIONE COMPOUNDS WITH ANTIVIRAL ACTIVITY
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, (2021/10/02)
Provided herein are methods of using substituted azole dione compounds for treatment of viral infections.
Photo-Ni-Dual-Catalytic C(sp2)-C(sp3) Cross-Coupling Reactions with Mesoporous Graphitic Carbon Nitride as a Heterogeneous Organic Semiconductor Photocatalyst
Antonietti, Markus,Ghosh, Indrajit,K?nig, Burkhard,Khamrai, Jagadish,Savateev, Aleksandr
, p. 3526 - 3532 (2020/04/09)
The synergistic combination of a heterogeneous organic semiconductor mesoporous graphitic carbon nitride (mpg-CN) and a homogeneous nickel catalyst with visible-light irradiation at room temperature affords the C(sp2)-C(sp3) cross-co
Compounds with anti-cancer activity
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, (2008/12/08)
Novel substituted azole diones are provided that kill cells, suppress cell proliferation, suppress cell growth, abrogate the cell cycle G2 checkpoint and/or cause adaptation to G2 cell cycle arrest. Methods of making and using the invention compounds are provided. The invention provides substituted azole diones to treat cell proliferation disorders. The invention includes the use of substituted azole diones to selectively kill or suppress cancer cells without additional anti-cancer treatment. The invention includes the use of cell cycle G2-checkpoint-abrogating substituted azole diones to selectively sensitize cancer cells to DNA damaging reagents, treatments and/or other types of anti-cancer reagents.
Modified Ullmann coupling of 2-chloro-3-trifluoromethylpyridine
Munavalli, S.,Rossman, D. I.,Szafraniec, L. L.,Beaudry, W. T.,Rohrbaugh, D. K.,et al.
, p. 1 - 6 (2007/10/02)
The application of the modified Ullmann reaction to 2-chloro-3-trifluoromethylpyridine furnishes 5,5'-bis(trifluoromethyl)-2,2'-bipyridine as the primary product, accompanied by small amounts of the expected 3,3'-bis(trifluoromethyl)-2,2'-bipyridine, 2-benzyl-3-(trifluoromethyl)pyridine, bibenzyl, 3-trifluoromethylpyridine, 3-methylpyridine, 2-hydroxyethyl-(3-trifluoromethylpyridyl) ether and 2-hydroxyethyl-(3-methylpyridyl) ether.For comparison purposes, a sample of 3,3'-bis-(trifluoromethyl)-2,2'-bipyridyl was prepared by the treatment of 2,2'-bipyridyl-3,3'-dicarboxylic acid with sulfur tetrafluoride.The formation of all but two compounds mentioned above can be rationalized on the basis of the single-electron-transfer process. - Keywords: Ullman coupling; Chlorotrifluoromethylpyridine; Bis(trifluoromethyl)bipyridine; Synthesis; NMR spectroscopy; Mass spectrometry
