175210-52-3Relevant academic research and scientific papers
Optimization of peptide-based inhibitors targeting the HtrA serine protease in Chlamydia: Design, synthesis and biological evaluation of pyridone-based and N-Capping group-modified analogues
Hwang, Jimin,Strange, Natalie,Phillips, Matthew J.A.,Krause, Alexandra L.,Heywood, Astra,Gamble, Allan B.,Huston, Wilhelmina M.,Tyndall, Joel D.A.
supporting information, (2021/07/16)
The obligate intracellular bacterium Chlamydia trachomatis (C. trachomatis) is responsible for the most common bacterial sexually transmitted infection and is the leading cause of preventable blindness, representing a major global health burden. While C.
Structure-based design of non-peptidic pyridone aldehydes as inhibitors of interleukin-1β converting enzyme.
Golec, Julian M. C.,Mullican, Michael D.,Murcko, Mark A.,Wilson, Keith P.,Kay, David P.,Jones, Stuart D.,Murdoch, Robert,Bemis, Guy W.,Raybuck, Scott A.,Luong, Yu-Ping,Livingston, David J.
, p. 2181 - 2186 (2007/10/03)
Pyridone derivatives, especially with 6-aryl substituents, have been shown to be useful P2-P3 peptidomimetic scaffolds for the design of potent inhibitors of ICE.
