175229-63-7Relevant academic research and scientific papers
Expeditious syntheses of conjugated allenyl esters and oxazoles through a cascade reaction of α-alkynyl malonates under alkaline conditions
Sano, Shigeki,Shimizu, Hisashi,Kim, Kweon,Lee, Woo Song,Shiro, Motoo,Nagao, Yoshimitsu
, p. 196 - 203 (2007/10/03)
Diethyl α-alkynyl-α-methoxymalonates (2a-e) were smoothly hydrolyzed and then decarboxylated under alkaline conditions employing 1 N KOH in EtOH to give conjugated allenyl esters (6a-e) in high yields, and similar alkaline treatment of diethyl α-alkynyl-α
Syntheses and Reactions of the Diethyl α-Alkynylmalonates Involving the Generation of Conjugated Allenyl Esters as the Latent Active Species: A New Approach to the Development of Cysteine Proteinase Inhibitors
Nagao, Yoshimitsu,Kim, Kweon,Sano, Shigeki,Kakegawa, Hisao,Lee, Woo Song,Shimizu, Hisashi,Shiro, Motoo,Katunuma, Nobuhiko
, p. 861 - 864 (2007/10/03)
Various diethyl α-alkynylmalonates (DAM) having potential as cysteine proteinase inhibitors were synthesized by treatment of diethyl acetyliminomalonate (or ketomalonate) with several lithium acetylides. Hydrolytic decarboxylation of the DAM under the mil
