175229-61-5Relevant academic research and scientific papers
Syntheses and Reactions of the Diethyl α-Alkynylmalonates Involving the Generation of Conjugated Allenyl Esters as the Latent Active Species: A New Approach to the Development of Cysteine Proteinase Inhibitors
Nagao, Yoshimitsu,Kim, Kweon,Sano, Shigeki,Kakegawa, Hisao,Lee, Woo Song,Shimizu, Hisashi,Shiro, Motoo,Katunuma, Nobuhiko
, p. 861 - 864 (1996)
Various diethyl α-alkynylmalonates (DAM) having potential as cysteine proteinase inhibitors were synthesized by treatment of diethyl acetyliminomalonate (or ketomalonate) with several lithium acetylides. Hydrolytic decarboxylation of the DAM under the mil
Expeditious syntheses of conjugated allenyl esters and oxazoles through a cascade reaction of α-alkynyl malonates under alkaline conditions
Sano, Shigeki,Shimizu, Hisashi,Kim, Kweon,Lee, Woo Song,Shiro, Motoo,Nagao, Yoshimitsu
, p. 196 - 203 (2007/10/03)
Diethyl α-alkynyl-α-methoxymalonates (2a-e) were smoothly hydrolyzed and then decarboxylated under alkaline conditions employing 1 N KOH in EtOH to give conjugated allenyl esters (6a-e) in high yields, and similar alkaline treatment of diethyl α-alkynyl-α
