175235-45-7Relevant academic research and scientific papers
Synthesis of 3-hydroxyindanones via potassium salt of amino acid catalyzed regioselective intramolecular aldolization of ortho-diacylbenzenes
Chanda, Tanmoy,Chowdhury, Sushobhan,Anand, Namrata,Koley, Suvajit,Gupta, Ashutosh,Singh, Maya Shankar
, p. 981 - 985 (2015/03/04)
First organocatalytic intramolecular aldolization of ortho-diacylbenzenes to construct highly functionalized 3-hydroxyindanones is described. In this transformation a high trans-selectivity is achieved by the use of metal salt of amino acid. This method allows an easy access to the strained spirocyclic 3-hydroxyindanones related to a number of natural product frameworks. Synthesis of a new class of indole skeleton substituted by 3-hydroxyindanones added an extra essence to this new protocol.
Palladium catalyzed cross-coupling acylation approach to the antitumor antibiotic Fredericamycin A
Evans, P. Andrew,Brandt, Thomas A.
, p. 1367 - 1370 (2007/10/03)
The palladium catalyzed cross-coupling of the organozinc reagent derived from 2-bromobenzaldehyde ethylene ketal 4 with the acyl chlorides 5 and 8 provides an expeditious route to the BCD 2 and BCDE 3 ring systems of Fredericamycin A 1.
