175277-85-7 Usage
Description
N1-(3-ETH-1-YNYLPHENYL)-2-CHLOROACETAMIDE is a chemical compound with the molecular formula C10H9ClNO. It is a derivative of acetamide, characterized by a chlorine atom attached to the second carbon of the acetamide group and a phenyl group connected to the nitrogen atom. The ethynyl group is positioned at the ortho position on the phenyl group. N1-(3-ETH-1-YNYLPHENYL)-2-CHLOROACETAMIDE holds potential in the realm of medicinal chemistry, particularly for the development of innovative pharmaceuticals, and may also be utilized in the synthesis of other organic compounds. Further research and testing are required to fully explore its potential applications and properties.
Uses
Used in Medicinal Chemistry:
N1-(3-ETH-1-YNYLPHENYL)-2-CHLOROACETAMIDE is used as a chemical intermediate for the development of new pharmaceuticals due to its unique structural features that may contribute to novel drug discovery and design.
Used in Organic Synthesis:
In the field of organic synthesis, N1-(3-ETH-1-YNYLPHENYL)-2-CHLOROACETAMIDE is used as a building block for the synthesis of other complex organic compounds, potentially leading to the creation of new materials or chemical entities with specific properties and applications.
Check Digit Verification of cas no
The CAS Registry Mumber 175277-85-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,5,2,7 and 7 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 175277-85:
(8*1)+(7*7)+(6*5)+(5*2)+(4*7)+(3*7)+(2*8)+(1*5)=167
167 % 10 = 7
So 175277-85-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H8ClNO/c1-2-8-4-3-5-9(6-8)12-10(13)7-11/h1,3-6H,7H2,(H,12,13)
175277-85-7Relevant articles and documents
Design and synthesis of novel pyridazine N-aryl acetamides: In-vitro evaluation of α-glucosidase inhibition, docking, and kinetic studies
Faramarzi, Mohammad Ali,Firoozpour, Loghman,Foroumadi, Alireza,Moghimi, Setareh,Mojtabavi, Somayeh,Sadat Ebrahimi, Seyed Esmaeil,Safari, Fatemeh,Salarinejad, Somayeh,Toolabi, Mahsa
, (2020)
We herein applied the four step-synthetic route to prepare the pyridazine core attached to the various N-aryl acetamides. By this approach, a new series of pyridazine-based compounds were synthesized, characterized and evaluated for their activities against α-glucosidase enzyme. In-vitro α-glucosidase assay established that twelve compounds are more potent than acarbose. Compound 7a inhibited α-glucosidase with the IC50 value of 70.1 μM. The most potent compounds showed no cytotoxicity against HDF cell line. Molecular docking and kinetic studies were performed to determine the modes of interaction and inhibition, respectively.