175278-00-9

Usage

Uses

Used in Chemical Synthesis:
1-Iodo-2-(trifluoromethoxy)benzene is used as a key intermediate in the synthesis of 2-(trifluoromethoxy)biphenylyl-2′-diazonium salts. Its unique structure and reactivity contribute to the formation of complex organic molecules that can be utilized in different industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1-Iodo-2-(trifluoromethoxy)benzene may be used as a building block for the development of new drugs. Its chemical properties allow for the creation of a wide range of compounds with potential therapeutic applications.
Used in Material Science:
1-Iodo-2-(trifluoromethoxy)benzene can be employed in the development of new materials with specific properties, such as improved stability or enhanced reactivity. Its unique structure can be exploited to create materials with tailored characteristics for various applications.
Used in Research and Development:
As a versatile chemical compound, 1-Iodo-2-(trifluoromethoxy)benzene is also used in research and development to explore new reactions and understand the underlying mechanisms. This knowledge can be applied to develop more efficient synthetic routes and innovative applications in various fields.

InChI:InChI=1/C7H4F3IO/c8-7(9,10)12-6-4-2-1-3-5(6)11/h1-4H

Upstream product

• 591-50-4 iodobenzene 
• 927-84-4 bis(trifluoromethyl)peroxide 
• 1197209-23-6 C₇H₄F₃NO₅S 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 2070902-77-9 trifluoromethyl 4-fluorobenzene-1-sulfonate 
• 1197209-28-1 trifluoromethyl 4-methoxybenzenesulfonate 
• 175676-42-3 trifluoromethyl 4-methylbenzenesulfonate 
• 1035797-66-0 benzoic acid trifluoromethyl ester 
• 456-55-3 1-trifluoromethoxybenzene 
• 334778-34-6 2-(trifluoromethoxy)phenyllithium 

Downstream Products

• 175676-54-7 2-amino-2'-(trifluoromethoxy)biphenyl 
• 1023306-57-1 2-(6-(2-(trifluoromethoxy)phenyl)-3(Z)-hexen-1,5-diynyl)aniline 
• 1070977-93-3 o-benzyl-α,α,α-trifluoromethoxybenzene 
• 1070977-91-1 2-allyl(trifluoromethoxy)benzene 
• 886503-02-2 2-(2-(trifluoromethoxy)phenyl)pyrrolidine 

Relevant academic research and scientific papers

Radical C?H Trifluoromethoxylation of (Hetero)arenes with Bis(trifluoromethyl)peroxide

Trifluoromethoxylated (hetero)arenes are of great interest for several disciplines, especially in agro- and medicinal chemistry. Radical C?H trifluoromethoxylation of (hetero)arenes represents an attractive approach to prepare such compounds, but the high cost and low atom economy of existing .OCF3 radical sources make them unsuitable for the large-scale synthesis of trifluoromethoxylated building blocks. Herein, we introduce bis(trifluoromethyl)peroxide (BTMP, CF3OOCF3) as a practical and efficient trifluoromethoxylating reagent that is easily accessible from inexpensive bulk chemicals. Using either visible light photoredox or TEMPO catalysis, trifluoromethoxylated arenes could be prepared in good yields under mild conditions directly from unactivated aromatics. Moreover, TEMPO catalysis allowed for the one-step synthesis of valuable pyridine derivatives, which have been previously prepared via multi-step approaches.

Photocatalytic trifluoromethoxylation of arenes and heteroarenes in continuous-flow

The first example of photocatalytic trifluoromethoxylation of arenes and heteroarenes under continuous-flow conditions is described. Application of continuous-flow microreactor technology allowed to reduce the residence time up to 16 times in comparison t

Trifluoromethyl aryl sulfonates (TFMS): An applicable trifluoromethoxylation reagent

Fluorine is probably another favorite hetero-atom for incorporation into small molecules after nitrogen. Among many fluorine-containing groups, trifluoromethyl aryl ethers (ArOCF3) have unique properties in drug design and are difficult to be synthesized, and many different methods were developed to prepare them. A novel one-pot synthesis of o-iodine-aryl trifluoromethyl ethers (ArOCF3I) was described by the reaction of trifluoromethoxylation and iodination with trifluoromethyl aryl sulfonates (TFMS) in this manuscript. The reaction conditions were optimized by screening different solvents, crown ethers, substrates and the ratios and the yields of products were in moderate to high yields (up to 86%).

Radical Trifluoromethoxylation of Arenes Triggered by a Visible-Light-Mediated N?O Bond Redox Fragmentation

A simple trifluoromethoxylation method enables non-directed functionalization of C?H bonds on a range of substrates, providing access to aryl trifluoromethyl ethers. This light-driven process is distinctly different from conventional procedures and occurs through an OCF3 radical mechanism mediated by a photoredox catalyst, which triggers an N?O bond fragmentation. The pyridinium-based trifluoromethoxylation reagent is bench-stable and provides access to synthetic diversity in lead compounds in an operationally simple manner.

Trifluoromethyl Benzoate: A Versatile Trifluoromethoxylation Reagent

Trifluoromethyl benzoate (TFBz) is developed as a new shelf-stable trifluoromethoxylation reagent, which can be easily prepared from inexpensive starting materials using KF as the only fluorine source. The synthetic potency of TFBz is demonstrated by trifluoromethoxylation-halogenation of arynes, nucleophilic substitution of alkyl (pseudo)halides, cross-coupling with aryl stannanes, and asymmetric difunctionalization of alkenes. The unprecedented trifluoromethoxylation-halogenation of arynes proceeds smoothly at room temperature with the aid of a crown ether-complexed potassium cation, which significantly stabilizes the trifluoromethoxide anion derived from TFBz.

Selective aromatic carbon-oxygen bond cleavage of trifluoromethoxyarenes: a trifluoromethoxy group as a convertible directing group

An efficient method for selective activation of aromatic C-O bonds in trifluoromethoxyarenes is developed. Upon treatment with a metallic sodium/chlorotrimethylsilane system, trifluoromethoxyarenes undergo reductive dealkoxylation to provide the corresponding arylsilanes. Also the synthetic applications of the present reactions combined with ortho-metallation are described.

2-, 3-, and 4-(Trifluoromethoxy)phenyllithiums: Versatile intermediates offering access to a variety of new organofluorine compounds

Consecutive treatment of (trifluoromethoxy)benzene with sec-butyllithium and electrophilic reagents affords previously inaccessible ortho-substituted derivatives in generally excellent yields. 2-(Trifluoromethoxy)phenyllithium acts as the key intermediate. The 3- and 4-isomers can readily be generated from the corresponding 3- and 4-bromo precursors by halogen-metal interconversion with butyllithium or tertbutyllithium. Upon trapping of the 2-, 3- and 4-(trifluoromethoxy)phenyllithiums with 11 different electrophiles the expected products were formed in generally high yields. Only the attempted nucleophilic addition of 2-(trifluoromethoxy)phenyllithium to oxirane did not succeed. This failure is tentatively attributed to a lowering of the nucleophilicity by fluorine-lithium interactions. Conformationally restricted analogs - i.e., 2,2-difluoro-1,3-benzodioxol-4-phenyllithium and its 5-fluoro- and 5-bromo-substituted congeners - did indeed react smoothly with oxirane, affording the adducts in ordinary yields.