175281-79-5

Basic information

• Product Name: Butanoic acid, 4-(4-acetyl-2-methoxyphenoxy)-, methyl ester
• CAS NO: 175281-79-5
• Molecular Formula: C14H18O5
• Molecular Weight: 266.294
• Mol File: 175281-79-5.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 4-(4-acetyl-2-methoxyphenoxy)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 4-(4-acetyl-2-methoxyphenoxy)-, methyl ester(175281-79-5)
• EPA Substance Registry System: Butanoic acid, 4-(4-acetyl-2-methoxyphenoxy)-, methyl ester(175281-79-5)

Safety Data

• Hazardous Substances Data: 175281-79-5(Hazardous Substances Data)

Upstream product

• 4897-84-1 Methyl 4-bromobutyrate 
• 584-08-7 potassium carbonate 
• 498-02-2 1-(3-methoxy-4-hydroxyphenyl)ethanone 
• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 

Downstream Products

• 1334290-05-9 4-(4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy)butan-1-ol 
• 1352127-36-6 4-(4-(1-(methacryloyloxy)ethyl)-2-methoxy-5-nitrophenoxy)butanoic acid 
• 1269794-14-0 2-((1-(4-(4-(2-(methacryloyloxy)ethylcarbamoyloxy)butoxy)-5-methoxy-2-nitro-phenyl)ethoxy)carbonylamino)ethyl methacrylate 
• 1352127-37-7 1,1'-(4,4'-(4,4'-(ethane-1,2-diylbis(azanediyl))bis(4-oxobutane-4,1-diyl))bis(oxy)bis(5-methoxy-2-nitro-4,1-phenylene))bis(ethane-1,1-diyl)bis(2-methyl acrylate) 
• 1091595-09-3 4-(4-(1-(acryloyloxy)ethyl)-2-methoxy-5-nitrophenoxy)butanoic acid 
• 1363555-53-6 C₁₆H₁₈ClNO₇ 
• 182297-45-6 methyl 4-(4-acetyl-2-methoxy-5-nitrophenoxy)butyrate 
• 188891-20-5 N-benzyl-4-[4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy]butyramide 
• 188891-19-2 N-benzyl-4-(4-acetyl-2-methoxy-5-nitrophenoxy)butyramide 
• 188891-23-8 methyl 4-(4-(1-aminoethyl)-2-methoxy-5-nitrophenoxy)butanoate 
• 175281-76-2 4-[4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy]butanoic acid 
• 188891-18-1 4-(4-acetyl-2-methoxy-5-nitrophenoxy)butanoic acid 

Relevant articles and documents

PDD AND BPD COMPOUNDS

The invention relates to pyrridinobenzodiazepines (PDDs) comprising three fused 6-7- 6–membered rings and to benzopyrridodiazecines (BPDs) comprising three fused 6-8- 6–membered rings and, in particular, to PDD or BPD dimers linked together or PDD and BPD monomers linked to aromatic groups, and pharmaceutically acceptable salts thereof, which are useful as medicaments, such as anti-proliferative agents. PDDs and BPDs may be represented by formula (I): and salts or solvates thereof, wherein R2, R4-R6 and R8 are independently selected substituent groups; and either: (i) R9 and R10 together form a double bond; (ii) R9 is H and R10 is OH; or (iii) R9 is H and R10 is ORA and RA is C1-6 alkyl; wherein each of m, n, u and w may be 0 or 1; where (a) the compound is a dimer with each monomer being the same or different and being of formula (I) where one of R1, R2, R3 and R7 of the first monomer and one of R'1, R'2, R3 and R'7 of the second monomer form together a bridge having the formula –X-L-X'- linking the monomers and m + n + u + w = 1; or (b) a dimer and one of R1, R2 and R3 of the first monomer and one of R'1, R'2 and R3 of the second monomer form together a bridge having the formula –X-L-X'- linking the monomers and m = n = u = w = o; or (c) one of R1, R2, R3 and R7 has the formula: –X- L-X'-D or -(CH2)f-O-R14 and m + n + u + w = o or 1; or (d) R7 has the formula: –X-L-X'- D or -(CH2)g-O -15 and m + n + u + w = 1; and X-L-X'- is a linker group and D has the formula (II) or (III):

Dual stimuli-responsive poly(2-hydroxyethyl methacrylate-co-methacrylic acid) microgels based on photo-cleavable cross-linkers: PH-dependent swelling and light-induced degradation

Dual stimuli-responsive p(HEMA-co-MAA) microgels were prepared in a facile way by inverse miniemulsion copolymerization of 2-hydroxyethyl methacrylate (HEMA) with methacrylic acid (MAA) and two kinds of newly synthesized photodegradable cross-linkers. The pH-dependent swelling behavior induced by the protonation/deprotonation of the methacrylic acid groups in the network-forming polymer was investigated by means of the particle volume change as determined by DLS measurements. Photolytic degradation experiments were conducted by irradiation with UV light which led to particle disintegration caused by cleavage of the photolabile cross-linking points. The degradation behavior of the microgels was investigated with respect to degradation rates and changes in the degree of swelling. Those parameters were found to depend on the pH value of the solvent, the light intensities, and the irradiation wavelengths applied. For similar conditions, the degradation profile was demonstrated to strongly depend not only on the molecular structure of the cross-linking molecule but also on the molecular weight of the network-forming copolymers. The particular combination of the stimuli described is designed as a new strategy to two different swelling/degradation profiles. This dual stimuli-responsiveness was shown to enable the efficient loading and subsequent release of myoglobin as a model protein. Here a slow diffusion controlled release (induced by changes of the pH) was combined with a fast degradation controlled (induced by irradiation) on-demand release. This novel two-step release profile is proposed to bear great potential for delivery applications.

Photolabile compounds and methods for their use

Novel compounds are provided which are useful as photocleavable linking groups in solid phase synthesis. Compositions incorporating these linking groups and methods for their use are also described.